Registration Dossier
Registration Dossier
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EC number: 200-740-6 | CAS number: 70-54-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Year:
- 1 997
- Bibliographic source:
- [WU,X, SKOG,K AND JAEGERSTAD,M; TRIGONELLINE, A NATURALLY OCCURRING CONSTITUENT OF GREEN COFFEE BEANS BEHIND THE MUTAGENIC ACTIVITY OF ROASTED COFFEE?; MUTAT. RES. 391(3):171-177
Materials and methods
- Principles of method if other than guideline:
- Standard plate (compound heated at 250 °C for 20 min)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- DL-lysine
- EC Number:
- 200-740-6
- EC Name:
- DL-lysine
- Cas Number:
- 70-54-2
- Molecular formula:
- C6H14N2O2
- IUPAC Name:
- DL-lysine
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 98
- Metabolic activation:
- with
- Metabolic activation system:
- Rat liver S9, chlorophene
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- not specified
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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