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EC number: 297-474-6 | CAS number: 93572-43-1 A complex combination of hydrocarbons obtained by refining of crude oil. It consists predominantly of aromatics, naphthenics and paraffinics and produces a finished oil with a viscosity of 120 SUS at 100°F (23cSt at 40°C).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Summary study report
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS
- Author:
- American Petroleum Institute
- Year:
- 2 003
- Bibliographic source:
- ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS pag 38-39
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Groups of 5 male and 5 female rats were exposed to oil mists
generated from two highly refined oils. Exposures were by
inhalation six hours each day for a total of 10 days
The two oils were examined in separate experiments. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Two samples of highly refined, solvent extracted dewaxed paraffinic base oil
- IUPAC Name:
- Two samples of highly refined, solvent extracted dewaxed paraffinic base oil
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- Six hours per day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Controls: Air only Oil 1: 55, 507 and 1507 mg/m3 Oil 2: 50, 513 and 1480 mg/m3
Basis:
nominal conc.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 50 mg/m³ air
- Based on:
- not specified
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Oil 1
All treated animals survived to study termination. The fur of all animals was saturated with test material and the amount of material present was clearly related to the exposure concentration. Alopecia and scabs subsequently formed in the highest 2 dose groups. Animals in the highest dose group were relatively unresponsive to auditory stimulation. Decreased body weight associated with a decrease in food consumption was recorded for the high dose animals. Biologically significant increases in relative lung and liver weights were observed in he males and females in the high dose group but only in the mid dose females. An increase in white cell counts and the percentage of neutrophils and a decrease in the percentage lymphocytes was observed in the high dose groups only. There were no treatment related histopathological changes in the lowest 2 dose groups. Animals in the highest dose group exhibited the same changes as those observed in the nasoturbinates and lungs of animals exposed to oil 2.
Oil 2
Clinical observations were the same as for those animals exposed to Oil 1, except that there was no scabbing and no treatment related alterations in food consumption. There was a biologically significant increase in absolute and relative lung weights in males and females at the high dose and in females only at the mid dose. Apart from elevated liver alanine and aspartate transaminase levels in the high dose females there were no other treatment related effects. Histological effects considered to be treatment related consisted of an increase in the amount of perivascular and peribronchial lymphoid proliferations and an increase in mixed inflammatory cell infiltrations in the terminal bronchioles and alveolar ducts of the highest two dose groups. Increases in the appearance of focal hyperplasia and squamous cell metaplasia of the anterior nasal mucosa associated with inflammatory cell infiltration were observed in the two highest dose groups. These changes were indicative of mild irritation of the nasal mucosa.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.