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EC number: 203-402-6 | CAS number: 106-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on generations indicated in Effect levels (migrated information)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from review article (report on chlorophenols - systematic review and critical evaluation of relevant data). Basic data given.
- Principles of method if other than guideline:
- Reproductive toxicity study - (long-term) oral exposure
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: drinking water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- ca. 6 months (pre-and postnatal exposure of progeny)
- Details on study schedule:
- Dams were exposed from 3 weeks of age through gestation gestation (bred at day 90 d) and lactation (12-14/group).
The progeny from each dose regime was continued on treatment from three weeks of age (weaning) until tumour development, death or termination of the study at 24 months (24-28 animals of each sex/group).
Eight randomly selected pups from each group were weaned at 3 weeks of age and continued on treatment for 10-15 weeks. - Remarks:
- Doses / Concentrations:
500 mg/L
Basis:
nominal in water
(equivalent to 50 mg/kg bw/d) - Remarks:
- Doses / Concentrations:
50 mg/L
Basis:
nominal in water
(equivalent to 5 mg/kg bw/d) - Remarks:
- Doses / Concentrations:
5 mg/L
Basis:
nominal in water
(equivalent to 0.5 mg/kg bw/d) - Control animals:
- yes, concurrent vehicle
- Positive control:
- Not applicable.
- Parental animals: Observations and examinations:
- BODY WEIGHT: Yes
- Time schedule for examinations: Body weight gain prior to breeding
OTHER:
- Maternal toxicity (body weight gain prior to breeding) - Litter observations:
- REPRODUCTIVE PERFORMANCE
- conception
PARAMETERS EXAMINED
The following parameters were examined in F1 offspring:
- litter size [live and stillborn]
- number of of stillborn
- birth weight
- survival to weaning
- weaning weight - Postmortem examinations (offspring):
- SACRIFICE / EFFECT ON THE PROGENY
- body weight gain
- weight of thymus
- spleen and liver at termination
- haematology (red and white blood cell counts, packed cell volume, mean corpuscular volume, haemoglobin)
- immunocompetence (cell-mediated immunity, humoral immunity, number and phagocytic activity of peritoneal macrophages) at termination - Dose descriptor:
- NOAEL
- Remarks:
- maternal
- Effect level:
- 50 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: No maternal toxicity.
- Dose descriptor:
- NOAEL
- Remarks:
- reproduction
- Effect level:
- 5 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Litter size decreased and the number of stillborn increased at 500 mg/L.
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 5
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: After 52 weeks: Increased red blood cell count, packed cell volume, and haemoglobin content.
- Reproductive effects observed:
- not specified
Reference
However, according to ATDR (1999), there is limited evidence that 2 -chlorophenol may reduce litter sizes when administered to rats in drinking water (Exon and Koller 1985).This effect was significant only at p≤0.1 and was observed at doses that caused other effects (e.g., increased liver weights, decreased delayed-type hypersensitivity).
Reference: ATDR, 1999. Toxicological profile for Chlorophenols, U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, July 1999, p. 126. [external reference]
Effect on fertility: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 5 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Estimated Klimisch Rating: 2
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Based on a two-year chronic drinking-water study with 2-chlorophenol (2-MCP) (read-across), in a screening test rats were exposed at dose rates of 0.5, 5, 50 mg/kg bw/d (pre-and postnatal exposure of progeny). Maternal toxicity was not observed at any concentration tested (P generation). The NOAEL for reproductive toxicity was deemed as 5 mg/kg bw/d. Furthermore, extension of the exposure of the dams through lactation, followed by exposure of the progeny for additional 10 - 15 weeks, did not result in effects on the progeny exposed both pre-and postnatally (at any concentration; F1 generation).
Short description of key information:
No data are available on the test substance. However, some data are available for 2-chlorophenol (2-MCP) based on a screening test in rats (drinking-water study) with 0.5, 5, 50 mg/kg bw/d. No maternal toxicity was observed at a dosage of 50 mg/kg bw/d. The NOAEL for reproductive toxicity was deemed as 5 mg/kg bw/d.
Justification for selection of Effect on fertility via oral route:
Data from review article (report on chlorophenols - systematic review and critical evaluation of relevant data). Basic data given.
The substance in the test was 2-chlorophenol.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
Due to the DSD classification (Table 3.2) and Seveso II Data, the test substance is considered not to be classified under Directive 67/548/EEC, as amended for the 31st time in Directive 2009/2/EG.
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
Based on the harmonized classification – Annex VI – Regulation (EC) No 1272/2008, the test substance is considered not to be classified under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation No 605/2014.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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