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EC number: 208-011-4 | CAS number: 505-52-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
All three in vitro studies were GLP compliant and of high quality (Klimisch score:1) and were clearly negative. The results are acceptable for the human health risk assessment.
Justification for selection of genetic toxicity endpoint
All three studies were clearly negative so no key study was selected.
Short description of key information:
Gene mutation (Bacterial Reverse Mutation Assay/Ames test): the substance tridecanedioic acid (CAS No. 505-52-2) did not induce mutagenicity using S. typhimurium TA 98, TA 100, TA 1535, TA 1537 and TA 102 in the presence or absence of Aroclor 1254 –induced rat liver S9 metabolic activation (OECD 471, GLP);
Chromosome aberration (in vitro mammalian cell micronucleus test): the substance tridecanedioic acid (CAS No. 505-52-2) does not induce an increase in micronucleus frequencies in Chinese hamster ovary (CHO-K1) cells in the presence or absence of Aroclor 1254 –induced rat liver S9 metabolic activation (OECD 487, GLP);
Gene mutation (in vitro mammalian cell gene mutation): the substance tridecanedioic acid (CAS No. 505-52-2) does not induce gene mutations in mouse lymphoma L5178Y cells in the presence or absence of Aroclor 1254 induced rat liver S9 metabolic activation (OECD 476, GLP).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available information in the dossier, the substance tridecanedioic acid (CAS No. 505-52-2)
does not need to be classified for germ cell mutagenicity when the criteria outlined in Annex I of 1272/2008/EC are applied.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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