Octa-1,7-diene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VII

Author:

Smyth H.F.; Carpenter, C.P.; Weil C.S.; Pozzani, U.C.; Striegel, J.A.; Nycum, J.S.

Year:

1969

Bibliographic source:

American Industrial Hygiene Association Journal 30: 470 - 476

Reference 2

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

Smyth H.F.; Carpenter, C.P.; Weil C.S.; Pozzani, U.C.; Striegel, J.A.

Year:

1962

Bibliographic source:

American Industrial Hygiene Association Journal 23: 95 - 107

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

(groups of 4 rabbits, occlusive treatment, limited documentation on e.g. on test method and test animals)

GLP compliance:

no

Remarks:

study performed prior to implementation of GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Octa-1,7-diene

EC Number:

223-054-9

EC Name:

Octa-1,7-diene

Cas Number:

3710-30-3

Molecular formula:

C8H14

IUPAC Name:

octa-1,7-diene

Details on test material:

- Name of test material (as cited in study report): 1,7-Octadiene
- Analytical purity: no data

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

- Weight at study initiation: 2.5 - 3.5 kg

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Details on dermal exposure:

TEST SITE
- Area of exposure: trunk
- Type of wrap if used: impervious plastic film

Duration of exposure:

24 h

Doses:

no data

No. of animals per sex per dose:

4 males

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

Based on mortality, LD50 value and its fiducial range were estimated by the method of Thompson using the Tables of Weil.

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

14.1 mL/kg bw

Based on:

test mat.

95% CL:

> 4.66 - < 42.9

Remarks on result:

other: original value as given in the publication

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

10 293 mg/kg bw

Based on:

test mat.

Remarks on result:

other: calculated with the density = 0.73 g/mL

Applicant's summary and conclusion

Conclusions:

In a skin penetration study, that was performed with groups of 4 rabbits treated with different doses of the test substance (24 h, occlusive) a LD50 value of 14.1 mL/kg bw (corresponding to 10293 mg/kg bw). No details on the results were available and only little information on the test method, test animals and test substance were provided. Thus, the data was not sufficient for assessment. However, the LD50 value indicated that classification for acute dermal toxicity is not warranted.