Registration Dossier
Registration Dossier
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EC number: 470-680-5 | CAS number: 958872-63-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Knowledge about well known analogeous substances, i.e. bicyclic terpene hydrocarbons like borneol, camphen, pinenes
Data source
Materials and methods
Results and discussion
Any other information on results incl. tables
The substance is formally an ether of isoborneol with two (iso)propanole chains. It has a low solubility in water, for renally
excretion improvement by glucuronidation or conjugation with sulfate or acetate etc. is necessary. This may be possible
directly on the alcohol–group of the side chain or after a hydroxylation of a methyl-group of the molecule.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Ether bindings are split up during metabolism in mammalian organism slowly.
The decomposition of the molecule should lead to isoborneol, which is excreted mainly via lungs (about 70 percent) due to its
volatility or hydroxylated and excreted with urine. Isoborneol can also be secreted by gall bladder with bile. This metabolic
pathways seems also possible for the substance itself. - Executive summary:
There are no toxicokinetic studies for this substance, but a transfer of knowledge about well known bicyclic terpene hydrocarbons like borneol, camphen, pinenes can give relevant hints for metabolism:
The substance is formally an ether of isoborneol with two (iso)propanole chains. It has a low solubility in water, for renally excretion improvement by glucuronidation or konjugation with sulfate or acetate etc. is necessary. This may be possible directly on the alcohol–group of the side chain or after a hydroxylation of a methyl-group of the molecule.
Ether bindings are splitted up during metabolism in mammalian organism slowly. The decomposition of the molecule should lead to isoborneol, which is excreted mainly via lungs (about 70 percent) due to its volatility or hydroxylated and excreted with urine. Isoborneol can also be secreted by gall bladder with bile. This metabolic pathways seems also possible for the substance itself
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