Registration Dossier
Registration Dossier
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EC number: 420-640-8 | CAS number: 138495-42-8
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Since the substance is not classified for mutagenicity and there is no evidence from an extended inhalation exposure study that the substance produces hyperplasia and/or pre-neoplastic lesions, the substance is currently considered non-carcinogenic.The substance does not need to be classified for carcinogenicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Additional information
The test substance did not produce mutagenicity or genetic damage when tested in bacterial and mammalian cell cultures or in laboratory animals. Carcinogenicity via genetic mechanisms is not predicted. Additionally, no tissue damage or systemic effects were observed during repeated inhalation studies. Carcinogenicity by epigenetic mechanisms is not predicted. The lack of active genetic and epigenetic effects supports the position that carcinogenicity is not likely a concern with this test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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