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EC number: 941-702-5 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 September 2015 to 28 November 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.319 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5 g/L
- Temp.:
- 20 °C
- pH:
- 6.7 - 6.8
- Water solubility:
- 0.306 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 1.5 g/L
- Temp.:
- 20 °C
- pH:
- 6.7 - 6.8
- Water solubility:
- 0.309 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 0.5 g/L
- Temp.:
- 20 °C
- pH:
- 6.7 - 6.8
- Details on results:
- Preliminary test
The content of test item dissolved in the water sample was 0.281 g/l.
Main study
The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analysed concentrations. The water solubility of the test item was independent from the loading rate.A small response was observed in the treated sample from the blank water mixture. Its contribution to the concentration in the water-solubility samples, however, was negligible. - Conclusions:
- The water solubility of the test item at 20°C was 0.309 g/l at loading rate 0.5 g/l. The water solubility of the test item at 20°C was 0.306 g/l at loading rate 1.5 g/l. The water solubility of the test item at 20°C was 0.319 g/l at loading rate 5 g/l. Accordingly the water solubility of Phenol, 1,1-dimethylpropyl derivs. did not depend from the investigated loading rate.
- Executive summary:
The purpose of the study was to determine the physico-chemical properties for Phenol, 1,1-dimethylpropyl derivs.
The study was performed to the following guidelines:
European Community (EC), EC no. 260/2014, Part A: Methods for the Determination of Physico-Chemical Properties, Guideline A.6: “Water Solubility”, Official Journal of the European Union no. L81, March 19, 2014.
Organization for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals no. 105: "Water Solubility", July 27, 1995.
United States Environmental Protection Agency (EPA), Product Properties Test Guidelines no. OPPTS 830.7840: "Water Solubility: Column Elution Method; Shake Flask Method", March 1998.
The flask method was applied for the determination of the water solubility of Phenol, 1,1-dimethylpropyl derivs.
The water solubility of the test item at 20°C was 0.309 g/l at loading rate 0.5 g/l.
The water solubility of the test item at 20°C was 0.306 g/l at loading rate 1.5 g/l.
The water solubility of the test item at 20°C was 0.319 g/l at loading rate 5 g/l.
Accordingly the water solubility of Phenol, 1,1-dimethylpropyl derivs. did not depend from the investigated loading rate.
The pH of the aqueous samples was 6.7 – 6.8.
Reference
Main study – water solubility of the test item at loading rate 0.5 g/l
Stirring time [hours] |
Analysed concentration [g/l] |
Mean [g/l] |
MD [%] |
pH |
24 48 72 |
0.305 0.311 0.310 |
0.309 |
2.1 |
6.7 6.7 6.8 |
Main study – water solubility of the test item at loading rate 1.5 g/l
Stirring time [hours] |
Analysed concentration [g/l] |
Mean [g/l] |
MD [%] |
pH |
24 48 72 |
0.305 0.309 0.303 |
0.306 |
2.1 |
6.8 6.7 6.8 |
Main study – water solubility of the test item at loading rate 5 g/l
Stirring time [hours] |
Analysed concentration [g/l] |
Mean [g/l] |
MD [%] |
pH |
24 48 72 |
0.314 0.322 0.322 |
0.319 |
2.6 |
6.8 6.8 6.8 |
Description of key information
Key value determined using the flask method in a GLP accredited laboratory study performed in accordance with OECD Guideline 105, EU Method A.6 and US EPA Procedure OPPTS 830.7840.
Key value for chemical safety assessment
- Water solubility:
- 0.319 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item at 20°C was 0.309 g/l at loading rate 0.5 g/l.
The water solubility of the test item at 20°C was 0.306 g/l at loading rate 1.5 g/l.
The water solubility of the test item at 20°C was 0.319 g/l at loading rate 5 g/l.
Accordingly the water solubility of Phenol, 1,1-dimethylpropyl derivs. did not depend from the investigated loading rate.
The pH of the aqueous samples was 6.7 – 6.8.
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