Registration Dossier
Registration Dossier
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EC number: 246-386-6 | CAS number: 24650-42-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- Anonymous
- Year:
- 2 013
- Bibliographic source:
- OECD Toolbox v3.1
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 476 (In Vitro Mammalian Cell Gene Mutation Test)
- GLP compliance:
- not specified
- Type of assay:
- mammalian cell gene mutation assay
Test material
- Reference substance name:
- 2,2-dimethoxy-1,2-diphenylethan-1-one
- EC Number:
- 246-386-6
- EC Name:
- 2,2-dimethoxy-1,2-diphenylethan-1-one
- Cas Number:
- 24650-42-8
- Molecular formula:
- C16H16O3
- IUPAC Name:
- 2,2-dimethoxy-1,2-diphenylethan-1-one
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with
- Metabolic activation system:
- S9
Results and discussion
Test results
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with
- Genotoxicity:
- positive
- Remarks:
- with 80 % certainty
- Cytotoxicity / choice of top concentrations:
- not determined
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive with 80 % certainty
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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