Registration Dossier
Registration Dossier
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EC number: 431-060-1 | CAS number: 153719-38-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- LOAEL
- 500 mg/kg bw/day
Additional information
- Effects on reproduction: At 500 mg/kg bw/d increased post natal loss and lower body weights of the pups. These results were considered to be due to parental toxicity following treatment with the test item. The NOAEL was 150 mg/kg bw/d.
- General toxic effects on parental animals observed at 150 mg/kg bw/d. This is consistent with an in 1997 conducted 28-d repeated dose oral toxicity study, where the LOAEL was determined to 85 mg/kg bw/d.
Short description of key information:
A Klimisch-1-rated One-Generation Reproduction Toxicity Study in the Han Wistar Rat (oral route) was conducted in 2009. No classification proposed for CA 23453 as to its effects on fertility.
Effects on developmental toxicity
Description of key information
A Klimisch-1-rated One-Generation Reproduction Toxicity Study in the Han Wistar Rat (oral route) was conducted in 2009. No classification proposed for CA 23453 as to its developmental toxicity.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- LOAEL
- 150 mg/kg bw/day
Additional information
Effects on pup growth: At 150 mg/kg bw/d (dose of P animals) reduced body weight of pups. These results were considered to be due to parental toxicity following treatment with the test item. The NOEL was 50 mg/kg bw/d.
Justification for classification or non-classification
Since the toxic effects on fertility of parents and development of offspering were observed at relatively high concentrations only, where also general toxic effects start coming into play, for CA 2343 A no classification is proposed as to its reprotoxic properties.
Additional information
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