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EC number: 285-077-0 | CAS number: 85029-52-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 14 july 2006 to 08 August 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the OECD internationally recognised guideline and according to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Acquapol C1
- IUPAC Name:
- Acquapol C1
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material: Acacia mearnsi extract
- Purity: 100%
- Substance type: UVCB
- Other: aqueous solution of quaternary ammonium tannate
- Physical state: liquide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: between 8 and 12 weeks
- Weight at study initiation: between 171 and 229g
- Fasting period before study: 12 hours
- Housing: polypropylene boxes covered by metal grid and lined with wooden shavings, with a maximum number of 5 animals per box
- Diet (e.g. ad libitum): commercial feed ad libitum
- Water (e.g. ad libitum): filtered water ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12h/12h
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - 1000 mg/mL, dose of 2000 mg/kg
- Doses:
- - Pre-test : 2000 mg/kg of live weight
- Final test : 2000 mg/kg of live weight - No. of animals per sex per dose:
- - Pre-test : one animal (female) per doses
- Final test : 5 animals (female) per doses - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: at the beginning and at the end of the study
- Necropsy of survivors performed: yes (heart, lung, liver, stomach, intestines, kidneys, adrenal glands and spleen)
- Other examinations performed: clinical signs (skin, hair, eyes, mucosae, circulatory, respiratory, nervous systems, somatomotor) and behavioral activity
Results and discussion
- Preliminary study:
- - Pre-test, one female rat oraly exposed at the dose of 2000 mg/kg of live weight: no death, the animal did not show clinical signs of toxicity
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Number of deaths: 0
- Clinical signs:
- other: - The animals did not show clinical signs of toxicity
- Other findings:
- - Other observations: respiratory system, cadiovasculatory system, digestive system, genitourinary system: not noteworthy up to the dose of 2000 mg/kg of live weight
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- - By oral route in the condition of the test, the substance is not toxic. According to the criteria given in Annex I of Regulation EC/1272/2008, the substance Acacia mearnsi extract should not be classified as hazadous for acute oral toxicity.
- Executive summary:
The Acute Oral Toxicity Test-Fixed Dose for rats was conducted to study the potential toxic effects of ACQUAPOL C1. The product was used in pure form (liquid) and administrated orally to rats that were 8 - 12 weeks old, at the dose of 2000 mg/kg of live weight in the pre-test, and at the dose of 2000 mg/kg of live weight for the final test. The animals were observed for time to death, behavioral changes, clinical signs and macroscopic anatomopathological findings. The final test was conducted with a dose of 2000 mg/kg of live weight, in which the animals do not present clinical signs of toxicity, which allows the product ACQUAPOL C1 to be classified in toxicological class V (Non-toxic) according to the classification table for acute toxicological risk according to GHS-OECD by oral route. Moreover, according to the criteria given in Annex I of Regulation EC/1272/2008, the substance Acacia mearnsi extract should not be classified as hazadous for acute oral toxicity in the testing conditions (LD50 > 2000 mg/kg of live weight).
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