Registration Dossier
Registration Dossier
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EC number: 200-813-2 | CAS number: 74-83-9
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.12 (Mutagenicity - In Vivo Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- yes
- Remarks:
- This test differs from the prescribed test method (EC B12) in that 50 cells per animal were examined as opposed to 100 cells per animal.
- Principles of method if other than guideline:
- The method used was an in-house method, details of which are described. When the study was performed no compulsory methodology was in existence.
- GLP compliance:
- no
- Remarks:
- No, the study was carried out before GLP became a mandatory requirement.
Test material
- Reference substance name:
- Bromomethane
- EC Number:
- 200-813-2
- EC Name:
- Bromomethane
- Cas Number:
- 74-83-9
- Molecular formula:
- CH3Br
- IUPAC Name:
- bromomethane
- Details on test material:
- Methyl Bromide: Batch no: 77371; purity not specified.
Constituent 1
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- There was no evidence for a mutagenic effect of Methyl Bromide in vivo in the Cytogenic tests.
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