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EC number: 237-048-9 | CAS number: 13597-46-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standards DIN 55992-1:2006 ("Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method"), modified Heubach method
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 55992-1:2006 (Determination of a parameter for the dust formation of pigments and extenders – Part 1: Rotation method)
- Deviations:
- yes
- Remarks:
- see "Principles of method if other than guideline"
- Principles of method if other than guideline:
- The Heubach dust meter is modified in a way that a seven stage cascade impactor is connected to the system. This involves an additional air fed of 20 L/min via the coarse dust separator needed to supply the cascade impactor with 40 L/min air current as specified in the manufacturer’s specifications.
- GLP compliance:
- no
- Type of method:
- rotating drum method
- Type of distribution:
- volumetric distribution
- Percentile:
- D75
- Mean:
- 26.17 µm
- Remarks on result:
- other: distribution fitted to cascade impactor data
- Percentile:
- D25
- Mean:
- 13.13 µm
- Remarks on result:
- other: distribution fitted to cascade impactor data
- Conclusions:
- -Total Dustiness (airborne fraction): 151.82 mg/g (experimental results, DMT Report).
- Mass median aerodynamic diameter of airborne fraction:
MMAD = 13.13 µm (p1=23.4 %) and MMAD = 26.17 µm (p2=76.6 %) (distribution fitted to cascade impactor data) *
- Geometric standard deviation of MMAD:
GSD = 3.95 (p1=23.4 %) and GSD = 1.79 (p2=76.6 %) *
- Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):
Head (ET): 52.55%
Tracheobronchial (TB): 0.40%
Pulmonary (PU): 0.83%
*The distribution consist basically of two combined lognormal distributions, which are weighted by a factor p.p2 is the weighing factor for the second distribution from a bimodal lognormal distribution, since p2 can be calculated from 1-p1 this parameter has not to be estimated separately but is reported here for the sake of clarity only . - Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-02-01 to 2010-02-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: 187: Particle Size Analysis by Laser Diffraction
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ISO13320-1: Particle Size Analysis - Laser Diffraction Methods
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2009-10-29
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
- Percentile:
- D10
- Mean:
- 3.9 µm
- St. dev.:
- 0.07
- Percentile:
- D50
- Mean:
- 17.4 µm
- St. dev.:
- 0.14
- Percentile:
- D90
- Mean:
- 45.4 µm
- St. dev.:
- 0.1
- Conclusions:
- The average of the median physical particle size of the test substance zinc selenite is L50 is 17.4 µm.
Referenceopen allclose all
Dustiness (airborne fraction): total: 151.82 mg/g.
In the original study report by DMT, a calculation of the mass median diameter was not conducted. Since the deposited fractions were provided for each of the cascade impactor stages, it was possible to fit a bi-modal lognormal distribution to the data by standard non-linear regression procedure. As a result, the MMAD and GSD are calculable and reported (p1: 23.4 %, MMAD1 = 13.13 µm, GSD1 = 3.95, p2: 76.6 %, MMAD2 = 26.17 µm, GSD2 = 1.79). As the cascade impactor already takes aerodynamic characteristics of the particles into account, the reported mass median diameter can be interpreted as the mass median aerodynamic diameter.
This figure and the corresponding GSD were used as distribution parameters for the MPPD model enabling an estimation of deposited dust fractions in the human respiratory tract: These fractions were estimated as follows:
Head (ET): 52.55%
Tracheobronchial (TB): 0.40%
Pulmonary (PU): 0.83%
Description of key information
(i) Total dustiness zinc selenite(airborne fraction): 151.82 mg/g (experimental result, DMT Report).
MMAD (bimodal distribution) of airborne fraction: MMAD = 13.13 µm (p1=23.4 %) and MMAD = 26.17 µm (p2=76.6 %) (distribution fitted to cascade impactor data, percentage in parentheses indicates weighting factor).
GSD of MMAD: 3.95 (p1=23.4 %) and GSD = 1.79 (p2=76.6 %)
Fractional deposition in human respiratory tract (MPPD model, based on calculated MMAD):
Head (ET): 52.55 %; Tracheobronchial (TB): 0.40 %; Pulmonary (PU): 0.83 %
(ii) Physical particle size: The average of the median physical particle size D50 is 17.4 µm (experimental result, laser diffraction, Krack, 2010)
Additional information
The test data on particle size (GLP, OECD guideline conform) is reliable without restrictions (Krack, 2010). Test procedure for the dustiness testing in accordance with national standards DIN 55992-1:2006 ("Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method"), modified Heubach method is reliable without restrictions. This Parr, 2010; Grewe, 2010 - study considers the airborne fraction of zinc selenite, which is exposure-related and relevant for workplace conditions. In the other study (Krack, 2010), the airborne fraction of zinc selenite was not determined, but the total of the substance used for particle size analysis. This is not exposure-related and not relevant for workplace conditions.
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