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EC number: 222-314-9 | CAS number: 3423-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 April - 26 July 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
- EC Number:
- 222-314-9
- EC Name:
- Endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
- Cas Number:
- 3423-25-4
- Molecular formula:
- C10H19NO
- IUPAC Name:
- Endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
- Test material form:
- solid: particulate/powder
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- Species: activated sludge, micro organisms from a domestic waste water treatment plant.
Origin: supplied by sewage plant Groß-Zimmern, Germany
Coditioning:
- The activated sludge used for this study was washed by centrifugation and the supernatant liquid phase was decanted. The solid material was resuspended in tap water and again centrifuged. This precedure was repeated twice.
- An aliquot of the final sludge suspension was weighed, dried and the ratio of wet sludge to its dry weight was determined. Based on this ratio, calculated aliquots of washed sludge suspension, corresponding to 3.9 g dry material per litre were mixed with test water and then aerated until use. Before use the sludge was filtered through cotton wooI. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2.12 mg/L
- Based on:
- ThOD
- Remarks:
- corresponding to 2.12 mg/L test item, respectively a ThODNH4 of about 5.41 mg 02/L
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Parameter:
- other: ThODN(NH4) and ThOD(NO3)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Under the test conditions the percentage biodegradation of NIsopropylnortropin was determined to be 0 % after 28 days of incubation,
based on ThODNNH4 and based on ThODN03. The test item can therefore be considered to be not ready biodegradable.
BOD5 / COD results
- Results with reference substance:
- The reference item Aniline was sufficiently degraded to a mean of 72 % after 14 days, and to a mean of 97 % after 28 days of incubation.
Any other information on results incl. tables
Table 1. Dissolved oxygen concentrations at different time intervals during the exposure period
of28 days
Treatment | Conc. [mg/L] | flask No. | mg O2 after n days of exposure | |||||||
0 | 1 | 5 | 7 | 12 | 14 | 22 | 28 | |||
Test Item | 2.12 | 1a | 8.4 | 8.4 | 8.4 | 8.3 | 8.3 | 8.2 | 8.2 | 7.8 |
1b | 8.4 | 8.5 | 8.5 | 8.4 | 8.3 | 8.3 | 8.1 | 7.8 | ||
mean | 8.4 | 8.45 | 8.45 | 8.35 | 8.3 | 8.25 | 8.15 | 7.8 | ||
Procedure Control (Aniline) | 2.02 | 2a | 8.4 | 8.5 | 7.0 | 5.6 | 5.2 | 4.7 | 4.0 | 3.0 |
2b | 8.4 | 8.5 | 7.4 | 5.6 | 5.2 | 4.8 | 4.2 | 3.2 | ||
mean | 8.4 | 8.5 | 7.2 | 5.6 | 5.2 | 4.75 | 4.1 | 3.1 | ||
Inoculum Control | _ | 3a | 8.4 | 8.5 | 8.5 | 8.3 | 8.4 | 8.2 | 8.1 | 7.7 |
3b | 8.4 | 8.5 | 8.4 | 8.4 | 8.3 | 8.3 | 8 | 7.9 | ||
mean | 8.4 | 8.5 | 8.45 | 8.35 | 8.35 | 8.25 | 8.05 | 7.8 | ||
Toxicity Control | TI: 2.04 Aniline: 2.14 | 4a | 8.4 | n.d | n.d | 6.8 | n.d | 4.8 | 4.2 | 3.4 |
4b | 8.4 | n.d | n.d | 7 | n.d | 4.6 | 4.1 | 3.2 | ||
mean | 8.4 | n.d | n.d | 6.9 | n.d | 4.7 | 4.15 | 3.3 |
n.d.: not determined
TI: test item
Table 2. Oxygen depletion at different time intervals during the exposure period of28 days
Treatment | Conc. [mg/L] | flask No. | O2 depletion (mg/L) after n days of exposure | ||||||
1 | 5 | 7 | 12 | 14 | 22 | 28 | |||
Test Item | 2.12 | 1a | 0.10 | 0.05 | 0.05 | 0.05 | 0.05 | -0.15 | 0.00 |
1b | 0.00 | -0.05 | -0.05 | 0.05 | -0.05 | -0.05 | 0.00 | ||
Procedure Control (Aniline) | 2.02 | 2a | 0.00 | 1.45 | 2.75 | 3.15 | 3.55 | 4.05 | 4.80 |
2b | 0.00 | 1.05 | 2.75 | 3.15 | 3.45 | 3.85 | 4.60 | ||
Inoculum Control | _ | mean | -0.10 | -0.05 | 0.05 | 0.05 | 0.15 | 0.35 | 0.60 |
Toxicity Control | TI: 2.04 Aniline: 2.14 | 4a | n.d | n.d | 1.55 | n.d | 3.45 | 3.85 | 4.40 |
4b | n.d | n.d | 1.35 | n.d | 3.65 | 3.95 | 4.60 |
n.d.: not determined
TI: test item
oxygen depletion : (lIlto - Il1tx) - (1lloo - IIlm), where:
mtO: oxygen concentration (mg/L) oftest item on day 0 (la and Ib, 2a and 2b or 4a and 4b from Table I)
mtx: oxygen concentration (mg/L) oftest item on day x (la and lb, 2a and 2b or 4a and 4b from Table I)
Ißt,o: oxygen concentration (mg/L) of inoculum blank on day 0 (mean of 3a and 3b)
mbx: oxygen concentration (mg/L) ofinoculum blank on day x (mean of3a and 3b)
Table 3. Percentage biodegradation, based on ThODNH4. at different time intervals during the exposure period of 28 days
Treatment | Conc. [mg/L] | flask No. | % biodegradation after n days exposure | ||||||
1 | 5 | 7 | 12 | 14 | 22 | 28 | |||
Test Item | 2.12 | 1a | 2 | -1 | 1 | 1 | 1 | -3 | 0 |
1b | 0 | -1 | -1 | 1 | -1 | -1 | 0 | ||
mean | 1 | 0 | 0 | 1 | 0 | -2 | 0 | ||
Procedure Control (Aniline) | 2.02 | 2a | 0 | 30 | 56 | 65 | 73 | 83 | 99 |
2b | 0 | 22 | 56 | 65 | 71 | 79 | 94 | ||
mean | 0 | 26 | 56 | 65 | 72 | 81 | 97 | ||
Toxicity Control | TI: 2.04 Aniline: 2.14 | 4a | n.d | n.d | 15 | n.d | 33 | 35 | 42 |
4b | n.d | n.d | 13 | n.d | 35 | 36 | 44 | ||
mean | n.d | n.d | 14 | n.d | 34 | 35 | 43 |
n.d.: not determined
TI: test item
BOD = mg 02/L of test item and/or Aniline - mg 02/L of inoculum control / mg test item and/or Aniline/L in flask
% biodegradation = BODx 100% / ThODNH4 of Aniline and/or test item
where: ThO~H4 oftest item = 2.55 mg 02/mg test item
ThO~H4 of Aniline = 2.41 mg 02/mg Aniline
Applicant's summary and conclusion
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Under the test conditions the percentage biodegradation of N-Isopropylnortropin was determined to be 0 % after 28 days of incubation, based
on ThODNNH4 and based on ThODN03.
The test item can be considered to be not ready biodegradable.
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