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EC number: 815-137-9 | CAS number: 573762-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 Jan 2021 to 23 Feb 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- July 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: MEP, P.R. China, the Guideline for the Testing of Chemicals, Degradation and Accumulation No. 301F “Manometric Respirometry Test”
- Version / remarks:
- Second Edition (2013.9)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidelines for the Testing of Chemicals, Revised Introduction to the OECD Guidelines for Testing of Chemicals, Section 3
- Version / remarks:
- March 2006
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile
- EC Number:
- 815-137-9
- Cas Number:
- 573762-62-6
- Molecular formula:
- C7H4F3N3
- IUPAC Name:
- 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile
- Details on test material:
- - Appearence : Slightly yellowish brown fine powder
- CAS Number: 573762-62-6
- Molecular formula: C7H4F3N3
- Molecular weight: 187.12
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Analytical purity: 99.7%
- Batch n°: BI03K2005005
- Expiration date: 2021-06-02 (re-test date)
- Purity test date: 2020-06-15 (certificate of analysis release date)
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition: at room temperature (15 - 25 °C)
- Stability under storage conditions: not indicated
- Stability under test conditions: not indicated
- Solubility or stability of the test item in the solvent/vehicle: not indicated
- Appearance: Almost white powder
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source: domestic wastewater treatment plant, Shenyang North, P.R. China
- Collection: 1 days before the test exposure was started
- Pretreatment: no
- Concentration of sludge: the concentration of inoculum was not greater than 30 mg/L (as suspended solids (SS)) - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 51.6 mg/L
- Based on:
- ThOD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: test water prepared according to test guidelines.
* mineral stock solution A: 4.2523 g KH2PO4, 10.8757 g K2HPO4, 16.7010 g Na2HPO4.2H2O in 1 L Milli-Q water
* mineral stock solution B: 0.2507 g NH4Cl dissolved in 1 L Milli-Q water
* mineral stock solution C: 36.4 g CaCl2.2H2O dissolved in 1 L Milli-Q water
* mineral stock solution D: 22.5 g MgSO4.7H2O dissolved in 1 L Milli-Q water
* mineral stock solution E: 0.25 g FeCl3.6H2O, 0.56 K2-EDTA dissolved in 1 L Milli-Q water
* For 1 liter of mineral medium, 10 mL stock solution A was added to approximately 800 mL distilled water and the mixture stirred before adding, sequentially, 1 mL each of stock solutions B, C and D. After mixing, the mixture was made up to 1 liter with distilled water. In total 2 replicates of 10 L mineral medium were prepared. The pH of the mineral medium were 7.59 and 7.58, respectively.
- Suspended solids concentration: initially 30 mg dw/L
- Continuous darkness: yes
SAMPLING
- Sampling frequency: every day during 28 days
CONTROL AND BLANK SYSTEM
- Biotic control: yes, two replicates with inoculum
- Toxicity control: yes
- Procedure control: yes, 1 replicate with reference substance and inoculum
Reference substance
- Reference substance:
- benzoic acid, sodium salt
- Remarks:
- sodium benzoate
Results and discussion
- Test performance:
- The positive control item was biodegraded by at least 60% within 14 days, confirming suitability of the activated sludge.
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Remarks on result:
- other: average of two replicates
- Details on results:
- The biodegradation of the reference substance (Sodium benzoate) attained 61.2% after day 4, 83.1% after 14 days and 94.3% after day 28.
Any other information on results incl. tables
In the Toxicity Control (TC) test mixture, more than 25% biodegradation occurred within 14 days (43.5%, based on ThOD). Therefore, the test item was considered not to inhibit microbial activity under test conditions.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the results, the percentage biodegradation of T003630 within 28 days did not exceed the pass level of 60% biodegradation based on ThOD. The test item did not meet the criteria for “ready biodegradability” under the described test conditions.
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