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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Jan 2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
1992
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
methyl cis-1-{[(2,5-dimethylphenyl)acetyl]amino}-4-methoxycyclohexanecarboxylate
EC Number:
606-524-1
Cas Number:
203313-47-7
Molecular formula:
C19H27NO4
IUPAC Name:
methyl cis-1-{[(2,5-dimethylphenyl)acetyl]amino}-4-methoxycyclohexanecarboxylate
Test material form:
solid: bulk

Results and discussion

Water solubility
Key result
Water solubility:
251 mg/L
Temp.:
20 °C
pH:
6.6

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
Executive summary:

The solubility in distilled water was determined according to the "flask method" described in the guidelines 92/69/EEC, appendix A.6.; OECD-guideline 105 and EPA Products Properties Guideline OPPTS 830.7840.


The concentration of was quantified by HPLC analyses.


The used HPLC method (reversed phase) was validated and found to be valid.


The purity of the test item (98.3 %) was taken into account.


 


Solubility in distilled water


















Solubility in



Measured pH 1)


 



CS


Solubility at 20°C



RSD



distilled water



6.6



251 mg/L



2.2 %


 



1) mean value from three 3 experiments