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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-11-11 to 2020-01-23
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187: Particle Size Analysis - Laser Diffraction Methods
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- - Batch No.: 2019002
- Purity: 98.39 %
- Physical state: White solid
- Storage conditions: Ambient temperature (10–30 °C)
- Expiry date: 2020-10-21 - Mass median aerodynamic diameter:
- >= 131 - <= 336 µm
- Key result
- Percentile:
- D50
- Mean:
- >= 131 - <= 336 µm
- Remarks on result:
- other: three test series
- Key result
- Percentile:
- D10
- Mean:
- >= 30 - <= 62 µm
- Remarks on result:
- other: three test series
- Key result
- Percentile:
- D90
- Mean:
- >= 436 - <= 981 µm
- Remarks on result:
- other: three test series
- Conclusions:
- The range of particle sizes of the test item deduced from the particle size distributions was:
L50: 131 to 386 µm
L10: 30 to 62 µm
L90: 436 to 981 µm - Executive summary:
In a GLP study conducted according to OECD TG 110, the particle size distriution was determined using the laser diffraction technique.
The particle size distribution was measured as dispersion in n-hexane in three test series.
The range of particle sizes of the test item deduced from the particle size distributions was
L50: 131 to 386 µmL10: 30 to 62 µm
L90: 436 to 981 µm
Reference
The particle size distribution showed considerably lower particle sizes in the first than in the second test series.
lt could not be excluded that the preparation of the first test series deviated from the second test series (e.g. longer preparation time). Therefore, a third test series was performed similar to the second test series. This showed comparable values both to the second test series as well as the microscopic image. ln order to further analyze this, the three measurements of each test series were evaluated. These measurements within a test series showed no temporal course.
However, the single measurements showed nevertheless significant deviations within a test series. Due to the results, it was concluded that the particle sizes within the test item were inhomogeneous (Due to the differences from the first test series to the second and third it cannot be completely excluded that the test item showed a minor solubility leading to smaller particle sizes in test series 1).
The inhomogeneous effect could have been amplified due to the small sample amount used in these tests (Due to the limited amount of sample available a dry dispersion could not be performed.)
As a consequence, the particle sizes of all three test-series will be given as range.
The particle size distributions determined in the test series are shown in the table below. Representative figures of the temporal courses (presented in percent by volume as a function of the particle size) of all three test-series are provided within the original report. Median values were calculated from unrounded values.
| L10* | L50** | L90*** |
1st test series | 30.8 µm | 151.5 µm | 436.4 µm |
2nd test series | 61.7 µm | 386.0 µm | 915.8 µm |
3rd test series | 53.7 µm | 332.3 µm | 980.3 µm |
Range | 30 – 62 µm | 131 – 386 µm | 436 – 981 µm |
*: 10 % of particle volume or particle mass with lower particle Diameter
**: median particle size: 50 % of particle volume or particle mass with lower particle Diameter
***: 90 % of particle volume or particle mass with lower particle Diameter
Description of key information
In a GLP study conducted according to OECD TG 110, the particle size distriution was determined using the laser diffraction technique.
The particle size distribution was measured as dispersion in n-hexane in three test series. The range of particle sizes of the test item deduced from the particle size distributions was:
L50: 131 to 386 µm
L10: 30 to 62 µm
L90: 436 to 981 µm
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.