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EC number: 406-140-2 | CAS number: 114369-43-6 INDAR
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24-March-1987 to 31-March-1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-(4-chlorophenyl)-2-phenyl-2-[(1H-1,2,4-triazol-1-yl)methyl]butanenitrile
- EC Number:
- 406-140-2
- EC Name:
- 4-(4-chlorophenyl)-2-phenyl-2-[(1H-1,2,4-triazol-1-yl)methyl]butanenitrile
- Cas Number:
- 114369-43-6
- Molecular formula:
- C19H17ClN4
- IUPAC Name:
- 4-(4-chlorophenyl)-2-phenyl-2-[(1H-1,2,4-triazol-1-yl)methyl]butanenitrile
- Test material form:
- solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Received from Hazleton Research Animals, Denver, PA.
- Age at study initiation: Approximately 12 weeks old
- Weight at study initiation: From 2.5 to 3.1 kg
- Housing: The animals were individually housed in stainless steel cages (18" x 24" x 15") suspended above absorbant paper pan liners which were changed 3 times a week.
- Diet: Approximately 225 g/day of Purina Laboratory Rabbit Chow High Fiber Diet
- Water: Filtered tap water (via automatic watering)
- Acclimation period: Approximately 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18°C
- Humidity (%): Between 40 and 60%.
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- The test item was ground in a mortar and pestle, and 0.1 g of the test material was applied to the corneal surface of the left eye of each rabbit.
- Duration of treatment / exposure:
- The treated and control eyes of three of the nine rabbits were irrigated with distilled water for approximately 60 seconds, beginning 20 to 30 seconds after dosing. The treated and control eyes of the remaining six animals were rinsed with water after the 24 hour observation for 30 to 60 seconds.
- Observation period (in vivo):
- 24, 48 and 72 hr and 7 days after dosing
- Number of animals or in vitro replicates:
- 9 male rabbits
- Details on study design:
- PREPARATION AND SELECTION OF ANIMALS: Upon arrival, all animals were examined for physical abnormalities, identified by uniquely numbered ear tags, and quarantined for approximately 2 weeks. One day prior to being dosed, nine healthy rabbits were selected from a stock population. All eyes were examined grossly and with an aqueous 2.0% sodium fluorescein solution. Rabbits with ocular abnormalities were excluded from the study.
SCORING SYSTEM: The degree of eye irritation was scored according to the procedure of Draize et al (J. Pharmacol. Exp. Therap., 82, 377-390, 1944).
TOOL USED TO ASSESS SCORE: When no gross lesions were evident on the cornea, the eyes were examined by using a 2.0% aqueous sodium fluorescein solution.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 6 animals (unwashed eyes) and 3 animals (washed eyes)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 6 animals (unwashed eyes) and 3 animals (washed eyes)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 6 animals (unwashed eyes) and 3 animals (washed eyes)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 6 animals (unwashed eyes) and 3 animals (washed eyes)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- No ocular effects were observed in the washed and unwashed treated eyes at any observation time. The eye irritation scores are detailed below (Table 1).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of an in vivo eye irritation study performed according to OECD guideline, the test item was concluded not to be irritant and/or corrosive to the eye.
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