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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June – September, 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
conducted under GLP conditions
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
0.002 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
20 mg/L
Incubation duration:
>= 72 - <= 96 h
Temp.:
20 °C
pH:
>= 6.6 - <= 6.7
Remarks on result:
other: Average of 72 hr and 96 hr samples
Details on results:
All tabulated values represent rounded-off results obtained by calculations based on the exact raw data. The fourth flask (168 h total contact time), foreseen as a back-up, was not analysed as the equilibrium was already reached after 72 h of contact time.

All tabulated values represent rounded-off results obtained by calculations based on the exact raw data. The pH values of the solutions in ultrapure water were pH 6.7 (48 h), pH 6.6 (72 h) and pH 6.7 (96 h).

No significant additional peaks were present in the chromatograms of the extracts from the aqueous solutions. It can therefore be concluded that the test substance does not undergo significant degradation in contact with water.

Contact Time (hours) Concentration in Aqueous Phase (mg/L)
48* 0.0012
72 0.0020
96 0.0018
(* saturation not attained by 48 hours incubation time)
Conclusions:
The results show that there is no significant change of the measured concentrations after 72 h and 96 h. Thus it can be concluded that equilibrium is reached. Thus the results obtained after 72 h and 96 h were averaged, to give the water solubility of GR-87-7596.

After rounding off:
Solubility of GR-87-7596 in water at 20°C: 0.0019 mg/L
Executive summary:

The solubility of GR-87-7596 in ultrapure water was determined according to the OECD Guideline No. 105 (flask method), based on analysis of the main constituent GR-87-7596.

The result is:

 

Solubility in water: 0.0019 mg/L at 20°C

 

This result corresponds to the saturation mass concentration of GR-87-7596 in ultrapure water at 20°C.

Description of key information

The solubility of GR-87-7596 in ultrapure water was determined according to the OECD Guideline No. 105 (flask method), based on analysis of the main constituent GR-87-7596.

The result is:

 

Solubility in water: 0.0019 mg/L at 20°C

 

This result corresponds to the saturation mass concentration of GR-87-7596 in ultrapure water at 20°C.

Key value for chemical safety assessment

Water solubility:
0.002 mg/L
at the temperature of:
20 °C

Additional information