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EC number: 406-250-0 | CAS number: 72619-32-0 HALOXYFOP R-(+)-ME HERBICIDAL CHEMICAL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- Intraperitoneal injection
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Pesticide Assessment Guidelines; Subdivision F - Hazard Evaluation: Human and Domestic Animals, Section 81-1, 1982
- Deviations:
- yes
- Remarks:
- dosed via intraperitoneal route
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Methyl (R)-2-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy)propionate
- EC Number:
- 406-250-0
- EC Name:
- Methyl (R)-2-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy)propionate
- Cas Number:
- 72619-32-0
- Molecular formula:
- C16H13ClF3NO4
- IUPAC Name:
- methyl 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- R Enantiomer of XRD-453 Methyl Ester
Lot # AGR 259823
Purity: 98.6%
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Doses:
- 100, 500 or 1000 mg test substance per kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- Means and standard deviations of body weights were calculated. The data were evaluated for statistical outliers by a sequential test, however, outliers were not excluded from statistical procedures if found. An approximate LD50 was obtained by nonlinear interpolation.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 224 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All males and females given 500 or 1000 mg/kg died by test day 3.
- Clinical signs:
- In-life observations of some rats that died consisted of lethargy, palpebral closure, lacrimation, facial/perineal soiling and labored respiration. Rats in the 100 mg/kg dose group were normal throughout the observation period.
- Body weight:
- All surviving rats gained weight by study termination.
- Gross pathology:
- Animals that died had nonspecific terminal changes consisting of perineal soiling with urine, facial soiling, visceral congestion, erosions and/or ulcers in the stomach and hemorrhage in the thymus. The origin of the blood in the urine of one male rat given 1000 mg/kg was not apparent. All male and female rats given 100 mg/kg were within normal limits.
Applicant's summary and conclusion
- Conclusions:
- Rat Intraperitoneal LD50 (male/female): 224 mg/kg
- Executive summary:
Five Fischer 344 rats per sex received a single intraperitoneal injection of 100, 500 or 1000 mg/kg of the test substance. Parameters examined during the two-week observation period included body weights and in-life observations.
All animals were examined for gross pathologic changes. All males and females given 500 or 1000 mg/kg died by test day three. In-life observations of some rats that died consisted of lethargy, palpebral closure, lacrimation, facial/perineal soiling and labored respiration. Rats in the 100 mg/kg dose group were normal throughout the observation period and gained weight by study termination. At necropsy, animals that died had nonspecific terminal changes. One male rat in the 1000 mg/kg dose group had blood in the urine; however, the origin was not apparent. All male and female rats given 100 mg/kg were within normal limits.
The acute intraperitoneal LD50 of the test substance was 224 mg/kg for male and female rats.
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