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Diss Factsheets
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EC number: 951-929-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- TOXICITY STUDIES OF TETRADECANOIC ACID, 2-SULFO-, 1-METHYLESTER, SODIUM SALT (C14-MES)
- Author:
- Jun SATO, Yasuhito YAMAMOTO, Tsuneaki NAKAMURA, Shigeru ISHIDA and Yutaka TAKAGI
- Year:
- 2 005
- Bibliographic source:
- The Journal of Toxicological Sciences, Vol.30, No.4, 339-347, 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Study from 2005
Test material
- Reference substance name:
- Sodium 1-methyl 2-sulphonatotetradecanoate
- EC Number:
- 223-675-5
- EC Name:
- Sodium 1-methyl 2-sulphonatotetradecanoate
- Cas Number:
- 4016-22-2
- Molecular formula:
- C15H30O5S.Na
- IUPAC Name:
- sodium 1-methoxy-1-oxotetradecane-2-sulfonate
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals and environmental conditions:
- purchased from Charles River Laboratories France (L’Arbresle Cedex, France)
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- not specified
- Concentration / amount:
- 0.1% intradermal
- Day(s)/duration:
- On Day 0
- Adequacy of induction:
- not specified
- Route:
- epicutaneous, open
- Vehicle:
- not specified
- Concentration / amount:
- 5% in induction patch
- Day(s)/duration:
- On day 7
- Adequacy of induction:
- not specified
- Route:
- epicutaneous, occlusive
- Vehicle:
- not specified
- Concentration / amount:
- 5% or 2%
- Day(s)/duration:
- On Day 14
- Adequacy of induction:
- not specified
- No. of animals per dose:
- 10
- Details on study design:
- We administered 0.1% C14-MES by intradermal injection into the shoulder of 10 guinea pigs on Day 0.
On Day 7, we applied a 48-hr filter paper (Whatman International Ltd, UK) induction patch containing 5% C14-MES to the injection site. Pretreatment with 0.5 mL of a suspension of 10% sodium lauryl sulphate in vaseline oil was performed 24-hr before the patch. We treated negative control animals with vehicle and positive control animals with 1% dinitrochlorobenzene (DNCB, Sigma). After 14 days, we applied 5% or 2% C14-MES on filter paper to the flank of animals as a 24-hr occlusive patch. We graded the skin reaction at 24 and 48-hr. - Positive control substance(s):
- yes
- Remarks:
- 1% dinitrochlorobenzene
Results and discussion
In vivo (non-LLNA)
Results
- Group:
- test chemical
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- The substance showed no allergenic potency in the male guinea pig under the experimental conditions.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance under investigation showed no allergenic potency in the male guinea pig under the experimental conditions.
- Executive summary:
A skin sensitization test on the substance under investigation according to the OECD guideline (OECD, 1992; Magnusson and Kligman, 1969) was performed on albino Hartley guinea pigs.
The substance under investigation showed no allergenic potency in the male guinea pig under the experimental conditions.
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