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Reaction mass of lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-[(4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)diazenyl]naphthalene-2,7-disulfonate and lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-{[4-(vinylsulfonyl)phenyl]diazenyl}naphthalene-2,7-disulfonate
EC number: 941-533-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05-03-2001 to 06-03-2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- The test substance was added to 130 mL of deionised water and stirred overnight before testing.
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Name and location of sewage treatment plant where inoculum was collected: aeration tank of a wastewater treatment plant treating predominantly domestic sewage (Wupper area water authority)
- Pretreatment: aeration of the activated sludge and daily feed with synthetic medium - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 18-22°C
- pH:
- 6.9
- Nominal and measured concentrations:
- Nominal: 100, 1000 and 10000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Sludge concentration (weight of dry solids per volume): 400 mg/L
- Nutrients provided for bacteria: synthetic medium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionised water
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : oxygen consumption of the activated sludge exposed to the test substance concentrations
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10 - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol at 5, 10 and 20 mg/L
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- The test substance caused only 8% respiration inhibition of the activated sludge microorganisms.
All validity criteria of the study were met and the study was considered acceptable. - Results with reference substance (positive control):
- The EC50 of the reference substance was determined to be 11 mg/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the nominal 3 h EC10 and EC50 of the test substance were >10000 mg/L.
- Executive summary:
A study was conducted to determine the toxicity of the test substance to wastewater sludge bacteria according to OECD Guideline 209 and EU Method C.11, in compliance with GLP. The activated sludge at the equivalent of 400 mg/L was exposed to nominal concentrations of 0, 100, 1000 and 10000 mg/L of the test substance for 3 h. The positive control or reference substance 3,5 -dichlorophenol was run in parallel at 5, 10 and 20 mg/L. Temperature, pH and oxygen inhibition were recorded at test start and end. The test substance caused only 8% respiration inhibition of the sludge bacteria. Under the study conditions, the nominal 3 h EC10 and EC50 of the test substance were >10000 mg/L (Müller, 2001).
Reference
Description of key information
The nominal 3 h EC10 and EC50 of the test substance were >10000 mg/L
Key value for chemical safety assessment
Additional information
A study was conducted to determine the toxicity of the test substance to wastewater sludge bacteria according to OECD Guideline 209 and EU Method C.11, in compliance with GLP. The activated sludge at the equivalent of 400 mg/L was exposed to nominal concentrations of 0, 100, 1000 and 10000 mg/Lof the test substance for 3 h. The positive control or reference substance 3,5 -dichlorophenol was run in parallel at 5, 10 and 20 mg/L. Temperature, pH and oxygen inhibition were recorded at test start and end. The test substance caused only 8% respiration inhibition of the sludge bacteria at the highest concentration of 10000 mg/L. Under the study conditions, the nominal 3 h EC10 and EC50 of the test substance were >10000 mg/L (Müller, 2001).
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