Registration Dossier
Registration Dossier
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EC number: 217-232-5 | CAS number: 1783-81-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Additional information
Justification for classification or non-classification
No experimental data are available for the assessment of repeated dose toxicity of 3-(methylthio)aniline.
The structure activity relationship of the substance was investigated in silico by using the QSAR Toolbox 4.3.1 (released 2019). The QSAR Toolbox refers to 'Thiocarbamates/Sulphides (Hepatotoxicity) No rank' with regard to repeated dose toxicity.
The Toxic hazard classification by Cramer is given with 'High (Class III) by the Toolbox.
Based on the structural similarity of 3-(methylthio)aniline to aniline (62 -53 -3) and the similarity of metabolism of both substances in rat liver simulated by the QSAR Toolbox, the experimental results for aniline will be taken over to 3 -(methylthio)aniline. Thus, 3 -(methylthio)aniline will be classified with STOT RE 1 (H372) in accordance to aniline as long as no experimental data are available for 3 -(methylthio)aniline itself
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