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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 470-270-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- yes
- Remarks:
- The relative humidity in the animal room was between approximately 30-82%. This deviation to the study plan, however, did not affect the validity of the study
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- -
- EC Number:
- 470-270-6
- EC Name:
- -
- Cas Number:
- 477773-67-4
- Molecular formula:
- C13H22N2O6K
- IUPAC Name:
- Glycine, N, N' - (1,9-nonandeiyl) bis-, monopotasium salt
- Test material form:
- solid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA/Ca
- Sex:
- female
- Details on test animals and environmental conditions:
- Source: Harlan Netherlands
Age: 7-8 weeks
Identification: Single caging. The animals were distributed into the test groups at random and identified by cage number.
Acclimatization: Under test conditions after health examination. Only animals without any visible signs of illness were used for the study.
Housing: single
Diet : Pelleted standard diet, ad libitum
Water: tap water from ad libitum.
ENVIRONMENTAL CONDITIONS:
Temperature: 22 ± 3 °C
Relative humidity: 30 - 82%
artifical light 6.00 am - 6.00 pm
Study design: in vivo (LLNA)
- Vehicle:
- other: ethanol:deionised water at a rate 7:3
- Concentration:
- 2,5 - 5 and 10%
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Statistics:
- A statistical analysis and standard deviations were calculated in the body weight tables
Results and discussion
- Positive control results:
- STIMULATION INDICES
2.04 (test item concentration 5% w/v) *
6.31 (test item concentration 10% w/v) *
12.45 (test item concentration 25% w/v)
EC3= 6.1%(w/v)
* This value was used in calculation of EC3
In vivo (LLNA)
Resultsopen allclose all
- Key result
- Parameter:
- SI
- Remarks:
- test item concentration % (w/v) 2.5
- Value:
- ca. 1.4
- Key result
- Parameter:
- SI
- Remarks:
- test item concentration % (w/v) 5
- Value:
- ca. 0.89
- Key result
- Parameter:
- SI
- Remarks:
- test item concentration % (w/v) 10
- Value:
- ca. 1.14
- Cellular proliferation data / Observations:
- Mortatlity / Viability: once daily (week day) from experimental start to necroposy
Body weights: prior to the first application and prior to treatment with 3HTdR
Clinical signs (local/systemic): once daily (week day). Especially the treatment sites were observed carefully
Any other information on results incl. tables
Stimulation Indices of 1.40, 8.89 and 1.14 were determined with the test item at concentrations of 2.5, 5 and 10 % in ethanol: water at a rate of 7:3. The EC3 value could not be calculated, since none of the tested concentrations induced an SI grater than 3.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not a skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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