Registration Dossier
Registration Dossier
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EC number: 208-883-6 | CAS number: 544-92-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Copper cyanide
- EC Number:
- 208-883-6
- EC Name:
- Copper cyanide
- Cas Number:
- 544-92-3
- Molecular formula:
- CCuN
- IUPAC Name:
- λ¹-copper(1+) iminomethanide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- Initial test: Apply 3 times, Maintains each 3 minutes, 1 hours, 4 hours.
Confirmatory test: Apply once and hold for 4 hours. - Observation period:
- 3 days
- Number of animals:
- 1 (Initial test), 2 (Confirmatory test)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- No erythema & eschar formation and edema were observed all animals(control site and test site). In the criteria for grading of skin reactions, evaluation score of control site and test site was 0, respectively.
- Other effects:
- Results were as follows;
1) There were no dead animals during the study.
2) There were no clinical signs related with treatment.
3) No test substance-related body weight changes were detected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, dermal irritation / corrosion of the test substance Copper cyanide(Copper(I) cyanide) in New Zealand White Rabbits was verified non-irritation / non-corrosion substance.
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