Registration Dossier
Registration Dossier
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EC number: 203-207-6 | CAS number: 104-49-4
Endpoint summary
Administrative data
Description of key information
Paraphenylene diisocyanate (PPDI) was not toxic to waste water bacteria (activated sludge) at or below a concentration of 320 mg/L (NOEC).
The EC10 was 401 mg/L (95% confidence interval: 264 - 609 mg/L).
The EC20 was 823 mg/L (95% confidence interval: 601 - 1126 mg/L).
The EC50 was above 1000 mg/L.
The EC50 value for P-phenylene diisocyanate at 48 hours was 4.46 mg/L based on nominal concentrations with fiducial limits at 95 % being 3.1463 and 6.3208 mg/L.
The EC50 value calculated for growth rate is 25.46 mg/L
The read across for pPDI is based upon the analogous substances to which basic form, degree of substitution of functional groups is not considered to effect the proposed read across for the endpoint of acute toxicity to fish. Based on the information available for the read across substances, the substance is not expected to be harmful to fish. Please refer to Section 13.2 "Other Assessment reports" for full justification, reference "pPDI+TDI READ ACROSS JUSTIFICATION".
Additional information
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