2-(1,3-dioxoisoindolin-2-yl)ethane-1-sulfonamide

Guidance on Safe Use

First-aid measures

Description of first aid measures:

Pay attention to self-protection.

Remove victims from hazardous area. Immediately remove soiled or soaked clothing and remove it to a safe distance. Keep victim warm, in a stabilized position and covered.

Do not leave victims unattended.

If the casualty is unconscious: Place the victim in the recovery position.

Inhalation:

Inhalation is possible if aerosols, mists, dusts, or smoke form.

Move victims into fresh air.

With labored breathing: Provide with oxygen. Consult a doctor.

If the casualty is not breathing: Perform mouth-to-mouth resuscitation, notify emergency physician immediately.

Skin contact:

Wash off affected area immediately with plenty of water for at least 15 minutes.

If symptoms persist, consult a physician for treatment.

Eye contact:

With eye held open, thoroughly rinse immediately with plenty of water for at least 10 minutes.

In case of persistent discomfort: Consult an ophthalmologist.

Ingestion:

Rinse mouth.

Immediately give large quantities of water to drink.

Obtain medical attention.

Most important symptoms and effects, both acute and delayed:

Symptoms: None known

Hazards: Other dangerous properties can not be excluded.

Indication of any immediate medical attention and special treatment needed:

This substance does not have any noteworthy noxious potential. Damage to health is thus not expected.

Fire-fighting measures

Extinguishing media:

Suitable extinguishing media:       

Dry powder

Alcohol-resistant foam

Water mist

Unsuitable extinguishing media: high volume water jet

Special hazards arising from the substance or mixture:

Hazard-determining flue gases might develop in case of fire:

nitrogen oxides (NOx)

Sulphur oxides

Carbon oxides

Advice for firefighters:

Contaminated extinguishing water must be treated at a suitable disposal plant in accordance with waste management laws.

Water used to extinguish fire should not enter drainage systems, soil or stretches of water.

In case of fire, remove the endangered containers and bring to a safe place, if this can be done safely.

Keep out unprotected persons.

Wear a self contained respiratory apparatus

Full protective suit

Accidental release measures

Personal precautions, protective equipment and emergency procedures:

Wear personal protective equipment; see section 8.

Avoid formation of dust. Ensure sufficient ventilation.

Keep out unprotected persons.

Environmental precautions:

Observe regulations on prevention of water pollution (check, dam up, cover up).

Do not allow entrance in sewage water, soil, stretches of water, drainage systems, surface water.

If the product contaminates rivers and lakes or drains inform respective authorities.

Methods and material for containment and cleaning up:

Absorb mechanically avoiding production of dust. Collect in suitable containers.

Disposal according to local authority regulations.

Reference to other sections

Wear personal protective equipment; see section "Exposure controls/personal protection"

Handling and storage

Precautions for safe handling:

Provide sufficient ventilation and exhaust at the workplace.

Prevent formation of dust.

Avoid contact with skin, eyes and clothing.

Avoid residues of the product on the containers.

Conditions for safe storage, including any incompatibilities:

Advice on protection against fire and explosion:

Keep away from combustion sources such as sparks, flames and unprotected light sources.

Take precautionary measures against static discharges.

Keep away from combustion sources such as sparks, flames and unprotected light sources.

When using do not smoke.

Take precautionary measures against static charges, keep away from sources of ignition.

Storage:

Store in the original receptacle, keeping this tightly sealed, under cool and dry conditions.

Further information:

In order to ensure due transportation, make certain that stacks are of the correct height, containers are securely fastened so as not to fall off, and labelled according to the regulations.

German storage class:

13 - Non Combustible Solids

Transport information

Land transport (UN RTDG/ADR/RID)

Shipping

Special provisions / remarks

Remarks:

Not dangerous according to transport regulations.

Inland waterway transport (UN RTDG/ADN(R))

Shipping

Special provisions / remarks

Remarks:

Not dangerous according to transport regulations.

Marine transport (UN RTDG/IMDG)

Shipping

Special provisions / remarks

Remarks:

Not dangerous according to transport regulations.

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Not dangerous according to transport regulations.

SpecialProvisions

Exposure controls / personal protection

Control parameters:

Exposure limit for dust:

CAS-No.                     

Control parameters: 10 mg/m3              Exposure limit(s):(TRGS 900)

type of exposure:

Inhalable fraction.

General dust limiting value(s):

Suitable measuring processes are:

BIA method 7284

      

Control parameters: 3 mg/m3                     Exposure limit(s):(TRGS 900)

type of exposure:

as alveolar accessible part

General dust limiting value(s):

Suitable measuring processes are:

BIA method 6068

TRGS 901, Part II, Number 96

DIN EN 481

Other information:

Contains no substances with occupational exposure limit values.

DNEL/DMEL values:

Remarks: No substance-related safety assessment is necessary / has been conducted for this product.

PNEC values:

Remarks: No substance-related safety assessment is necessary / has been conducted for this product.

Exposure controls:

Engineering measures:

Provide appropriate exhaust ventilation at machinery.

Provide for installation of emergency shower and eye bath.

Personal protective equipment:

Respiratory protection:

If breathable dusts and suspended matter occur: Use respiratory protective device with combination filter ABEK P3

in the event of prolonged exposure during handling:

wear a self contained respiratory apparatus

Note time limit for wearing respiratory protective equipment.

Hand protection:

Applies to handling for brief periods or of small amounts

Glove material       Nitrile

Material thickness: 0.11 mm

Method: DIN EN 374

Applies to handling for longer periods or of large amounts

Glove material       Nitrile/Chloroprene

Material thickness: 0.65 mm

Method: DIN EN 374

Selection of protective gloves to meet the requirements of specific workplaces.

Suitability for specific workplaces should be clarified with protective glove manufacturers.

The information is based on our own tests, references from the literature and information from glove manufacturers, or derived by

analogy with similar materials.

Remember that the useful time per day of a chemical protection glove may be much shorter than the permeation time determined

according to EN 374 due to the many different influential factors involved (e.g. temperature).

Eye protection:

Safety glasses with side-shields conforming to EN166

or

If dust occurs: basket-shaped glasses

Skin and body protection:

Select materials and equipment for physical protection depending on the concentration and volume of hazardous substances and the workplace involved.

Hygiene measures:

Do not eat, drink, smoke, or sniff while at work. Wash your hands and/or face before breaks and before termination of work.

Remove and wash contaminated clothing before re-use.

Preventive skin protection is recommended.

Use barrier cream regularly.

Protective measures:

Handle in accordance with good industrial hygiene and safety practice.

Avoid contact with skin, eyes and clothing.

If there is the possibility of skin/eye contact, the indicated hand/eye/body protection should be used.

The personal protective equipment used must meet the requirements of directive 89/686/EEC and amendments (CE certification).

It should be defined in the work place in the form of a risk analysis according to directive 89/686/EEC and amendments.

Stability and reactivity

Reactivity: No further information available

Chemical stability: The product is chemically stable.

Possibility of hazardous reactions: No dangerous reaction known under conditions of normal use.

Conditions to avoid:

Prevent the formation of dust.

Avoid contact with oxidizing substances.

Incompatible materials:Oxidizing agents

Hazardous decomposition products:

May be released in case of fire: carbon monoxide and carbon dioxide.

Nitrogen oxides (NOx)

Sulphur oxides

carbon monoxide, carbon dioxide

Disposal considerations

Waste treatment methods:

Product:

Disposal according to local authority regulations.

Pack and label wastes like the pure substance. Do not detach label from the delivery containers prior to disposal.

Uncleaned packaging:

Do not reuse empty containers and dispose of in accordance with the regulations issued by the appropriate local authorities.

Waste Key Number:

The waste key number must be determined as per the European Waste Types List (decision on EU Waste Types List 2000/532/EC) in cooperation with the disposal firm / producing firm / official authority.