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Diss Factsheets
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EC number: 252-809-5 | CAS number: 35947-07-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Test performance:
- Hydrolysis of Calcium Diglycinate was conducted at 50±0.5°C in buffer pH 4, 7 and 9 buffer solutions for a period of 5 days.
Based on the test results Calcium Diglycinate was found hydrolytically stable in
buffer pH 4, 7 and 9 buffers at 50C ± 5ºC.
Hydrolysis samples were analysed by H-NMR on Day 0 and Day 5 to study the
hydrolysis process of test item and observed that; shift in the chemical shift or delta value of specific proton in amino acid moiety of Calcium Diglycinate
The H-NMR analysis on Day 0 and Day 5 in different pH showed slight shift in delta value for CH2 proton in different pH buffers (buffer pH 7.0 and buffer pH 9.0). There is no extra peak observed other than CH2. This shift could be due to molecular association in different pH. Hence the shift in delta value cannot be attributed to the hydrolysis of ligand. There was no changes observed in buffer pH 4.0 on day 0 and day 5.
Hydrolysis samples were analysed by ICP-MS on Day 0 and Day 5 at 50 ± 0.5°C to
determine the total calcium content in the test item. Results showed that the total Calcium content remains unchanged.
Sterility was checked on Day 0 and Day 5 for each of the test systems (a single
sample from each pH buffer solution). There was no microbial growth of total
bacterial count and total yeast and mould count were observed. - Transformation products:
- no
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Validity criteria fulfilled:
- yes
- Conclusions:
- On the basis of test results, the test item was not hydrolyzed in buffer
pH 4, pH 7 and pH 9 at 50 ± 0.5ºC for 5 days. The test item was considered as
hydrolytically stable in buffer pH 4, pH 7 and pH 9 buffers. It concludes that the test item half-life is greater than 1 year (t1/2 >1 Year) in buffer pH 4, pH 7 and pH 9.
Reference
Description of key information
On the basis of test results, the test item was not hydrolyzed in buffer
pH 4, pH 7 and pH 9 at 50 ± 0.5ºC for 5 days. The test item was considered as
hydrolytically stable in buffer pH 4, pH 7 and pH 9 buffers. It concludes that the test
item half-life is greater than 1 year (t1/2 >1 Year) in buffer pH 4, pH 7 and pH 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 50 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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