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EC number: 211-838-3 | CAS number: 700-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19.06.2009 - 02.07.2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,3,5-trimethylhydroquinone
- EC Number:
- 211-838-3
- EC Name:
- 2,3,5-trimethylhydroquinone
- Cas Number:
- 700-13-0
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 2,3,5-trimethylhydroquinone
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): 2,3,5-Trimethylhydrochinone
- Physical state: solid
- Analytical purity: 99.64 area-%
- Lot/batch No.: 48/130509
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test solutions were prepared for each test concentration separately. The test item was added to the test medium and the mixture was stirred (magnetic stir plate) for about 4 hours at approximately 20°C.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: The clone of Daphnia magna STRAUS 1820 used in this study was originally obtained from the Institut National de Recherche Chimique Appliquée, France, in 1978. From this date on this clone was cultured and bred continuously in the Laboratory of Ecotoxicology of the Experimental Toxicology and Ecology of the BASF SE, Ludwigshafen, Germany.
- Age at study initiation (mean and range, SD): < 24 h
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 2.20 – 3.20 mmol/L
- Test temperature:
- 20 ± 1 °C
- pH:
- 7,5 - 8,5
- Conductivity:
- 550 - 650 µS/cm
- Nominal and measured concentrations:
- Nominal test concentrations:
0 (control), 0.46, 1.0, 2.2, 4.6, 10 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers (nominal volume 100 mL)
- Fill volume: 50 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 0.1 animals/mL
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: synthetic fresh water prepared generally according to OECD 202 for M4 medium
- Ca/mg ratio: about 4 : 1
- Conductivity: 550 - 650 µS/cm
OTHER TEST CONDITIONS
- Photoperiod: 16:8 h day-night regime
- Light intensity: About 20 – 850 lux at a wave length of 400 -750 nm
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mobility after 0, 24 and 48 hours
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 48 hour EC50: 1 - 10 mg/L - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (Kaliumdichromat, K2Cr2O7)
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 0.46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 2.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The test item is not completely stable in test media and quickly decomposes by oxidation. The results of this study should therefore be considered as the combined effect of the parent test item and all degradation products.
- Reported statistics and error estimates:
- Finney, D. J.: Probit analysis. Cambridge University Press, 3rd Edition, 1971
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a study according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test), a 48 h EC50 = 1,1 mg/L for trimethylhydroquinone was determined.
- Executive summary:
The acute toxicity of trimethylhydroquinone to Daphnia magna was investigated in a study according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) under static conditions. The endpoint examined was immobilization. The 48 h EC50 was determined to be 1,1 mg/L based on nominal concentrations.
The testing/validity criteria laid down in the OECD guideline 202 are fulfilled. This study is regarded as reliable without restriction. Thus, a 48 h EC50 = 1,1 mg/L has to be taken into account for the assessment of trimethylhydroquinone.
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