Registration Dossier
Registration Dossier
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EC number: 214-482-7 | CAS number: 1134-23-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- QSAR
- Justification for type of information:
- QSAR The bacterial in vitro genotoxicity QSAR prediction was assessed as adequate for regulatory purposes (Klimisch 2 – results derived from a valid QSAR model and falling into its
applicability domain, with adequate and reliable documentation/justification).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- no
Test material
- Reference substance name:
- Cycloate
- IUPAC Name:
- Cycloate
- Details on test material:
- Cycloate
Constituent 1
Results and discussion
Test results
- Key result
- Species / strain:
- other: Salmonella
- Remarks:
- QSAR
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Remarks:
- QSAR
- Cytotoxicity / choice of top concentrations:
- not determined
- Remarks:
- QSAR
- Vehicle controls validity:
- not specified
- Remarks:
- QSAR
- Untreated negative controls validity:
- not examined
- Remarks:
- QSAR
- Positive controls validity:
- not examined
Applicant's summary and conclusion
- Conclusions:
- Prediction NEGATIVE, based on a positive prediction probability equal to 0.093.
- Executive summary:
Ames test prediction for cycloate is NEGATIVE.
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