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EC number: 609-567-4 | CAS number: 38661-72-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 June 2017 - 24 August 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- Version / remarks:
- 23 March 2006
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: municipal sewage treatment plant: 'Waterschap Aa en Maas', 's-Hertogenbosch, The Netherlands,
- Storage conditions: not applicable, the freshly obtained sludge was used immediately.
- Preparation of inoculum for exposure: before use, the sludge was allowed to settle (40 minutes) and the liquid was decanted for use as inoculum at the amount of 10 mL/L of mineral medium.
- Concentration of sludge: 3.2 g suspended solids/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 3.5 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- TOC
- Initial conc.:
- 0.62 other: mg/mg
- Based on:
- ThIC
- Parameter followed for biodegradation estimation:
- inorg. C analysis
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral medium according to OECD guideline 310
- Test temperature: 19.7 and 24.1°C
- pH: 7.8 for the test item vessels (7.5-7.9 for controls)
- pH adjusted: no
- Aeration of dilution water: not indicated
- Suspended solids concentration: sludge liquid at an amount of 10 mL/L mineral medium (concentration of suspended solids not indicated)
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: well sealed glass serum vessels.
- Number of culture flasks/concentration: five test vessels for analysis at the end of the test and three test vessels for other time intervals for the test item and each of the control treatments.
- Method used to create aerobic conditions: not indicated
- Measuring equipment: Shimadzu TOC-VCPH total organic carbon analyser combined with a Shimadzu ASI-V autosampler
* Calibration solution: IC standard: sodium hydrogen carbonate/sodium carbonate solution
- Other: incubation was peformed in an orbital shaker, with a shaking rate sufficient to keep the vessel well mixed and in suspension.
SAMPLING
- Sample pretreatment: 1 mL 7 M NaOH was injected through the septum of each vessel and the vessels were returned to the orbital shaker for 1 h. Thereafter, the vessels were removed from the shaker and allowed to settle. The supernatant was used for IC analysis.
- Sampling frequency:
*inoculum blank and test item: day 1, 7, 14, 21 and 28
*procedure control and toxicity control: day 1, 7 and 14
*abiotic control: day 1 and 28
DETERMINATION OF BIODEGRADATION:
The CO2 evolution resulting from the aerobic biodegradation of the test item was determined by determining the inorganic carbon (IC) produced in the test item vessels in excess of that produced in the inoculum blank. Biodegradation was expressed as a percentage of the ThIC, based on the quantity of test item (as C) initially added.
CONTROL AND BLANK SYSTEM
- Inoculum blank: containing inoculated medium
- Abiotic sterile control: containing untreated medium, test item and 1 mL of a solution containing 10 g/L of HgCl2 as sterilising agent
- Toxicity control: containing inoculated medium, reference item and test item
- Procedure control: containing inoculated medium and reference item
- Reference substance:
- other: octan-1-ol
- Remarks:
- purity: 98%; ThIC: 0.74 mg/mg
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 3
- Sampling time:
- 28 d
- Details on results:
- - The value for biodegradation of the test item was corrected for degradation in the abiotic control (13%).
- In the toxicity control more than 25% biodegradation occurred within 14 days (45%, based on ThIC). Therefore, the test item was assumed not to inhibit microbial activity. - Results with reference substance:
- The reference item biodegraded for 105% after 14 days, indicating that the test system functioned properly.
- Validity criteria fulfilled:
- yes
- Remarks:
- see 'Overall remarks'
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Under the conditions of the Headspace Test, performed according to OECD guideline 310 and GLP conditions, FORTIMOTM 1,4-H6XDI was not readily biodegradable.
- Executive summary:
A Headspace Test was performed according to OECD guideline 310 and GLP principles, to assess the ready biodegradability of FORTIMOTM 1,4-H6XDI. Activated sludge was exposed to the test item at a concentration of 3.5 mg/L, corresponding to a organic carbon content of 20 mg/L, for 28 days. Octan-1 -ol was tested as reference substance (procedure control) and a blank control, abiotic control and toxicity control were included. Analysis of test item samples was performed at day 1, 7, 14, 21 and 28. Five replicates were used for the analysis at the end of the test and three replicates for analysis at other time intervals. The percentage biodegradation was determined by the amount of inorganic carbon produced in excess of the amount produced in the inoculum blank. Biodegradation was expressed as a percentage of the theoretical inorganic carbon (ThIC) based on the quantity of test item initially added. The ThIC of the test item was determined to be 0.62 mg/mg. At the end of the exposure period, the test item showed 3% biodegradation (corrected for degradation by the abiotic control (13%)) and thus the criterion for ready biodegradability (at least 60% biodegradation within a 10-day window) was not met. Since the reference item was biodegraded for 105% and the mean amount of ThIC present in the inoculum blanks at the end of the test was 2 mg/L, the test system was shown to function properly and the acceptability criteria were met. Also, based on the results of the toxicity control, the test item was found not to inhibit microbial activity. Under the conditions of this test, FORTIMO(TM) 1,4-H6XDI was not readily biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The rationale to read across the data is attached in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- yes
- Duration of test (contact time):
- d
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 3
- Sampling time:
- 28 d
- Details on results:
- - The value for biodegradation of the test item was corrected for degradation in the abiotic control (13%).
- In the toxicity control more than 25% biodegradation occurred within 14 days (45%, based on ThIC). Therefore, the test item was assumed not to inhibit microbial activity. - Results with reference substance:
- The reference item biodegraded for 105% after 14 days, indicating that the test system functioned properly.
- Validity criteria fulfilled:
- yes
- Remarks:
- see 'Overall remarks'
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Under the conditions of the Headspace Test, performed according to OECD guideline 310 and GLP conditions, FORTIMOTM 1,4-H6XDI was not readily biodegradable. This result is read across to 1,3-H6XDI.
- Executive summary:
A Headspace Test was performed according to OECD guideline 310 and GLP principles, to assess the ready biodegradability of FORTIMOTM 1,4-H6XDI. Activated sludge was exposed to the test item at a concentration of 3.5 mg/L, corresponding to a organic carbon content of 20 mg/L, for 28 days. Octan-1 -ol was tested as reference substance (procedure control) and a blank control, abiotic control and toxicity control were included. Analysis of test item samples was performed at day 1, 7, 14, 21 and 28. Five replicates were used for the analysis at the end of the test and three replicates for analysis at other time intervals. The percentage biodegradation was determined by the amount of inorganic carbon produced in excess of the amount produced in the inoculum blank. Biodegradation was expressed as a percentage of the theoretical inorganic carbon (ThIC) based on the quantity of test item initially added. The ThIC of the test item was determined to be 0.62 mg/mg. At the end of the exposure period, the test item showed 3% biodegradation (corrected for degradation by the abiotic control (13%)) and thus the criterion for ready biodegradability (at least 60% biodegradation within a 10-day window) was not met. Since the reference item was biodegraded for 105% and the mean amount of ThIC present in the inoculum blanks at the end of the test was 2 mg/L, the test system was shown to function properly and the acceptability criteria were met. Also, based on the results of the toxicity control, the test item was found not to inhibit microbial activity. Under the conditions of this test, FORTIMO(TM) 1,4-H6XDI was not readily biodegradable. This result is read across to 1,3-H6XDI.
Referenceopen allclose all
Table 1 Biodegradation in Percentage of theTheoretical maximum IC Production (ThIC)
Nominal day |
Microbial degradation in percentage of the ThIC |
Degradation |
||
Reference Item |
Test Item |
Toxicity Control |
Abiotic Control |
|
1 |
0 |
14 |
1 |
12 |
7 |
83 |
13 |
48 |
- |
14 |
105 |
16 |
45 |
- |
21 |
- |
18 |
- |
- |
28 |
- |
16 |
- |
13 |
- = Not measured
Table 1 Biodegradation in Percentage of theTheoretical maximum IC Production (ThIC)
Nominal day |
Microbial degradation in percentage of the ThIC |
Degradation |
||
Reference Item |
Test Item |
Toxicity Control |
Abiotic Control |
|
1 |
0 |
14 |
1 |
12 |
7 |
83 |
13 |
48 |
- |
14 |
105 |
16 |
45 |
- |
21 |
- |
18 |
- |
- |
28 |
- |
16 |
- |
13 |
- = Not measured
Description of key information
Under the conditions of the Headspace Test, performed according to OECD guideline 310 and GLP conditions, 1,4-H6XDI was not readily biodegradable. This result is read across to 1,3-H6XDI.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
A Headspace Test was performed according to OECD guideline 310 and GLP principles, to assess the ready biodegradability of 1,4-H6XDI. Activated sludge was exposed to the test item at a concentration of 3.5 mg/L, corresponding to a organic carbon content of 20 mg/L, for 28 days. Octan-1 -ol was tested as reference substance (procedure control) and a blank control, abiotic control and toxicity control were included. Analysis of test item samples was performed at day 1, 7, 14, 21 and 28. Five replicates were used for the analysis at the end of the test and three replicates for analysis at other time intervals. The percentage biodegradation was determined by the amount of inorganic carbon produced in excess of the amount produced in the inoculum blank. Biodegradation was expressed as a percentage of the theoretical inorganic carbon (ThIC) based on the quantity of test item initially added. The ThIC of the test item was determined to be 0.62 mg/mg. At the end of the exposure period, the test item showed 3% biodegradation (corrected for degradation by the abiotic control (13%)) and thus thecriterion for ready biodegradability (at least 60% biodegradation within a 10-day window) was not met. Since the reference item was biodegraded for 105% and the mean amount of ThIC present in the inoculum blanks at the end of the test was 2 mg/L, the test system was shown to function properly and the acceptability criteria were met. Also, based on the results of the toxicity control, the test item was found not to inhibit microbial activity. Under the conditions of this test, FORTIMO(TM) 1,4-H6XDI was not readily biodegradable. This result is read across to 1,3-H6XDI.
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