Registration Dossier
Registration Dossier
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EC number: 201-741-4 | CAS number: 87-39-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- OECD Toolbox Version 4.1. The toolbox is a software application to identify and fill (eco)toxicology data gaps for chemical hazard assessment. The toolbox is developed in cooperation with OECD and ECHA. For reference see www.qsartoolbox.org
Data source
Reference
- Reference Type:
- other: QSAR Toolbox prediction
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Guideline:
- other: REACH Guidance on QSARs R.6.
Test material
- Reference substance name:
- 5-hydroxyiminobarbituric acid
- EC Number:
- 201-741-4
- EC Name:
- 5-hydroxyiminobarbituric acid
- Cas Number:
- 87-39-8
- Molecular formula:
- C4H3N3O4
- IUPAC Name:
- 5-(hydroxyimino)-1,3-diazinane-2,4,6-trione
- Test material form:
- solid: particulate/powder
- Details on test material:
- Lot/batch No.: 201713807
Constituent 1
- Specific details on test material used for the study:
- SMILES: ON=C1C(=O)NC(=O)NC1=O
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 570 mg/kg bw
- Remarks on result:
- other:
- Remarks:
- QSAR predicted value
Any other information on results incl. tables
The OECD Toolbox version 4.1. was used for prediction of acute toxicity (LD50) and read-across were performed from related substances. Only the result in the applicability domain is accepted. The predicted LD 50 for the target substance 5-hydroxyiminobarbituric acid was 4570 mg/kg.
Thus, the QSAR prediction does not indicate alert for acute toxicity in relation to classification.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Test substance is not acute toxic based on OECD Toolbox prediction and read-across
- Executive summary:
The OECD Toolbox version 4.1. was used for prediction of acute toxicity (LD50) and read-across were performed from related substances. Only the result in the applicability domain is accepted. The predicted LD 50 for the target substance 5-hydroxyiminobarbituric acid was 4570 mg/kg. Thus, the QSAR prediction does not indicate alert for acute toxicity in relation to classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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