Registration Dossier
Registration Dossier
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EC number: 213-924-6 | CAS number: 1067-12-5
Endpoint summary
Administrative data
Description of key information
Biotic degradation
Experimental investigations showed that Tris(hydroxymethyl)phosphine oxide (THPO) has to be considered as “not readily biodegradable” by attaining only 7% degradation after 28 days in a GLP study according to OECD Guideline 301F.
Abiotic degradation
The potential of the substance THPO to hydrolyse under environmental conditions can be excluded due to the lack of functional groups. The -P-C-bonds of phosphine oxides and their closely related organophosphine oxides are expected to be resistant to hydrolysis. THPO is a triorganylphosphine oxide that has three hydrolysis resistant -P-C-bonds. Therefore, based on structural assessment (and experience in handling and use), the substance is not expected to undergo hydrolysis in the environment. In conclusion, this fate process will not contribute to a measurable degradative loss of the substance from the environment.
Bioaccumulation
The substance specific logPow (octanol-water partition coefficient) was predicted with KOWWIN v1.68 (by US EPA). The prediction results in a logPow of -4.77 and thus no potential for accumulation in aquatic biota is expected.
Moreover, a very low Bioconcentration factor can be predicted with BCFBAF v3.01 (by US EPA), concluding that any potential for bioaccumulation in aquatic organisms can be ruled out: BCF in fish of 3.16 L/kg w.w. concerning the traditional method (based on the logPow) and 0.893 L/kg w.w. based on the Arnot-Gobas method.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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