Registration Dossier
Registration Dossier
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EC number: 430-280-3 | CAS number: 844491-96-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From October 1997 to March 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Key result
- Type:
- log Pow
- Partition coefficient:
- < -2
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not determined
- Details on results:
- Average Pow = 0.000015
Standard deviation = 0.0000082
Decadic logarithm of the average Pow = - 4.8
Because very low log Pow values such as -4.8 may exhibit remarkable errors, the final results is given as log Pow = < -2. - Conclusions:
- Under the study conditions, the log Pow was of <-2 (average Pow = 0.000015).
- Executive summary:
A study was conducted to determine the partition coefficient of the test substance by the shake-flask method according to EU Method A.8, in compliance with GLP. The analytical method used was photometry. Under the study conditions, the log Pow was < -2 (average Pow = 000015) (Grosenick, 1997).
Reference
Description of key information
The partition coefficient was determined by the shake-flask method according to EU Method A.8 (Grosenick, 1997).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2
- at the temperature of:
- 25 °C
Additional information
< -2
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