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Diss Factsheets
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EC number: 236-526-4 | CAS number: 13419-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
It is assumed that structurally similar compounds should behave similarly under same 301 OECD test. However, published biodegradation data for substances containing both an acid or ester and a mercaptan functional group are in many cases contradictive (Rücker, et al. 2017).
Results of repeated biodegradation experiments for the same substance in the same test using inoculum from the same source may differ considerably. These findings are also supported by the relevant guidelines: “Realising that ready biodegradability tests may sometime fail because of the stringent test conditions, positive test results should generally supersede negative test results” (ECHA 2017, page 208; OECD 2006, page 3), and “When contradictory results in ready biodegradability tests are obtained the positive results could be considered valid irrespective of negative results, when the scientific quality of the former is good and the positive test results are well documented, …” (ECHA 2017, page 230).
Based on the above mentioned information, weight of evidence approach was taken to assess the biodegradability of the test substance. Following studies were taken into consideration (I) a study conducted according to OECD Guideline 301 B (Mead 2000) and (2) published data from the article (Rücker, et al. 2017), which provides results from OECD study 301 F.
In the study by Rücker, et al. 2017, 24 substances containing divalent sulfur, (i. e., mercaptocarboxylic acids, their esters, disulfides, sulfides and mercaptans) were tested in two standardised biodegradation tests, OECD 301 D (Closed Bottle Test, CBT) and OECD 301 F (Manometric Respirometry Test, MRT) in the same laboratory.
For most of the test substances strong differences between CBT (OECD 301 D) and MRT (OECD 301 F) results were observed with MRT test being more effective. For our substance of interest, MRT test biodegradation of 71.2 % in day 28 and a biodegradation of 12.4 % with CBT test were achieved. Based on the literature and experimental biodegradation information presented in the article, mercaptocarboxylic acids and their esters as a class are found to be either readily biodegradable or at least biodegradable to a significant extent.
Based on the weight of evidence approach, the test substance is concluded to be readily biodegradable.
ECHA, 2017: Guidance on information requirements and chemical safety assessments, Chapter R.7b: Endpoint specific guidance, June 2017,
OECD, 2006: Organisation for Economic Co-operation and Development, OECD Guidelines for the testing of chemicals, Revised introduction to the OECD Guidelines for testing of chemicals, Section 3, adopted 23 March 2006,
Rücker Ch., Mahmoud W. M. M., Schwartz D., Kümmerer K. Biodegradation tests of mercaptocarboxylic acids, their esters, re-lated divalent sulfur compounds, and mercaptans. Manuscript (24.11.2017).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.