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EC number: 938-572-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 16 October -to 13 November 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- GLP compliance is not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- The inoculum was prepared from activated sludge taken from a waste water treatment plant (Klagshamn, Sweden). The activated sludge contained 3.9 g/L suspended solids.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 68 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- The study was performed according to the SS-EN ISO 7827:1996/OECD 301A method, which monitors the fate of dissolved organic carbon (DOC) throughout the study.
Four solutions (A-D) were produced for use in creating the test, control, inhibition, sterile and blank mediums. Stock solutions for use in creating these mediums were produced for the reaction mass of 2-ethyl-2 -(methoxymethyl)-propane-1,3-diol and 2 -ethylpropane-1,3 –diol test substance (Di-methylolpropane technical grade-US) (concentration: 1000 mg/L), reference substance (sodium acetate) (concentration: 0.0137 mg/L), and sterile medium substance (mercury(II) chloride (HgCl2)) (concentration: 0.01 mg/L).
For the test:
4 L of test medium was prepared and 2 L was added in duplicate to 2 L flasks.
2 L of control medium was prepared and added to a 2 L flask.
2 L of inhibition medium was prepared and added to a 2 L flask.
0.5 L of sterile medium was prepared and added to a 0.5 L flask.
2 L of blank medium was prepared and added to a 2 L flask.
Each flask was assigned the project number, date and type of medium, and the level in the flask marked on the flask.
Flasks were incubated in a room with diffused light at room temperature (20-25°C). To maintain aerobic conditions in the mediums and obtain stirring, air was bubbled from an air pump through a long glass tube which ended at the bottom of the flask.
Before taking samples from flasks, water loss due to evaporation was made up with deionized water.
After sampling, a new marks was made at the new medium level.
The total organic carbon (TOC) concentration was measured in each flask on day 0 and 28.
The dissolved organic carbon (DOC) concentration was measured for each period (0, 7, 14, 21 and 28 days) in each inoculated flask. The DOC concentration in the flask with sterile medium was measured only on day 0 and 28.
The filter used for DOC samples was Scheicher & Schuell, (0.45 µm, OE 67, 45 mm), boiled 3 times in deionized water to purify the filters from soluble carbon. Each boiling period lasted for at least one hour.
The percentage degradation of TOC or DOC was calculated via the following equation:
DT = (1 - çt - çBt) / (ç0 - çB0)) * 100
Where:
ç0 = the concentration of TOC or DOC, at time 0, in each test flask FT
çB0 = the concentration of TOC or DOC, at time 0, in each blank flask FB
çt = the concentration of TOC or DOC, at time t, in each test flask FT
çBt = the concentration of TOC or faxDOC, at time t, in the blank flask FB - Reference substance:
- acetic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Remarks:
- (Flask 1)
- Value:
- 34
- Sampling time:
- 7 d
- Parameter:
- % degradation (DOC removal)
- Remarks:
- (Flask 2)
- Value:
- 25
- Sampling time:
- 7 d
- Parameter:
- % degradation (DOC removal)
- Remarks:
- (Flask 1)
- Value:
- 81
- Sampling time:
- 14 d
- Parameter:
- % degradation (DOC removal)
- Remarks:
- (Flask 2)
- Value:
- 80
- Sampling time:
- 14 d
- Parameter:
- % degradation (DOC removal)
- Remarks:
- (Flask 1)
- Value:
- 80
- Sampling time:
- 21 d
- Parameter:
- % degradation (DOC removal)
- Remarks:
- (Flask 2)
- Value:
- 78
- Sampling time:
- 21 d
- Parameter:
- % degradation (DOC removal)
- Remarks:
- (Flask 1)
- Value:
- 79
- Sampling time:
- 28 d
- Key result
- Parameter:
- % degradation (DOC removal)
- Remarks:
- (Flask 2)
- Value:
- 81
- Sampling time:
- 28 d
- Results with reference substance:
- > 90% degradation after 14 days.
- Validity criteria fulfilled:
- yes
- Remarks:
- Degradation of the reference compound after 14 days was >70%
- Interpretation of results:
- readily biodegradable
- Conclusions:
- In both test flasks, the test substance reaction mass of 2-ethyl-2 -(methoxymethyl)-propane-1,3-diol and 2 -ethylpropane-1,3 –diol achieved >70% biodegradation (loss of DOC) within 28 days within a 10-day window, and is therefore concluded to be readily biodegradable.
- Executive summary:
The biodegradability of reaction mass of 2-ethyl-2 -(methoxymethyl)-propane-1,3-diol and 2 -ethylpropane-1,3–diol was determined according to OECD guideline 301A (DOC Die away test). The amount of biodegradation observed comprised ca. 30% after 7 days and increased to ca. 81% after 14 days., therefore reaction mass of 2-ethyl-2 -(methoxymethyl)-propane-1,3-diol and 2-ethylpropane-1,3–diol can be classified as readily biodegradable and passing the 10 day window.
Reference
TOC-content (mg/L) during the study:
Day |
F(B) |
F(C) |
F(TI) |
F(TII) |
F(I) |
F(S) |
D(TI) |
D(TII) |
0 |
3 |
37 |
41 |
40 |
76 |
39 |
0 |
0 |
28 |
4 |
5 |
13 |
10 |
16 |
40 |
77 |
83 |
DOC-content (mg/L) during the study:
Day |
F(B) |
F(C) |
F(TI) |
F(TII) |
F(I) |
F(S) |
D(TI) |
D(TII) |
0 |
3 |
42 |
43 |
76 |
82 |
42 |
0 |
0 |
7 |
5 |
6 |
31 |
35 |
24 |
- |
34 |
25 |
14 |
4 |
4 |
12 |
12 |
15 |
- |
81 |
80 |
21 |
5 |
5 |
13 |
14 |
16 |
- |
80 |
78 |
28 |
5 |
5 |
13 |
12 |
15 |
43 |
79 |
81 |
Where:
FT: Test flasks containing sample and inoculum
FS: Control flask for non-biological degradation containing sample and mercury chloride
FB: Control flask for DOC contribution from the inoculum
FC: Flask containing the reference compoun (sodium acetate) for checking the activity of the inoculum
FT: Flask containing sample and the reference compound (sodium acetate) to check for any possible inhibitory effect of the sample on the inoculum
DT: Percent DOC reduction compared to day 0 after correction for the DOC contribution from the inoculum
Description of key information
Based on a reliable (Klimisch 2) experimental aerobic biodegradation study (according to the method SS-EN ISO 7827:1996/OECD 301A), reaction mass of 2-ethyl-2 -(methoxymethyl)-propane-1,3-diol and 2 -ethylpropane-1,3–diol is concluded to be readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
The biodegradability of reaction mass of 2-ethyl-2 -(methoxymethyl)-propane-1,3-diol and 2 -ethylpropane-1,3–diol was determined according to OECD guideline 301A (DOC Die away test). The amount of biodegradation observed comprised ca. 30% after 7 days and increased to ca. 81% after 14 days, therefore 2-ethylpropane-1,3-diol can be classified as readily biodegradable and passing the 10 day window.
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