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Diss Factsheets
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EC number: 237-044-7 | CAS number: 13597-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only abstract available.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- The fate of intragastrically or intratracheally administered or inhaled vanadium-48 oxydichloride in juvenile and mature rats
- Author:
- Sollenberger, D.M.
- Year:
- 1 982
- Bibliographic source:
- Dissertation Abstracts International, 42 (8): 3176-B.
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The objective of this research was to investigate the absorption of soluble vanadium (vanadium oxydichloride) from the respiratory tract of male Sprague Dawley rats of two ages.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- vanadium dichloride oxide
- IUPAC Name:
- vanadium dichloride oxide
- Reference substance name:
- Vanadium dichloride oxide
- EC Number:
- 233-517-7
- EC Name:
- Vanadium dichloride oxide
- IUPAC Name:
- 233-517-7
- Reference substance name:
- 10213-09-9
- Cas Number:
- 10213-09-9
- IUPAC Name:
- 10213-09-9
- Details on test material:
- - Name of test material (as cited in study report): Vanadium oxydichloride (labelled with vanadium-48)
No further information on the test material was stated.
Constituent 1
Constituent 2
Constituent 3
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Juvenile and mature rats
- Individual metabolism cages: yes
No further information on the test animals was stated.
Administration / exposure
- Route of administration:
- intratracheal
- Vehicle:
- not specified
- Details on exposure:
- A group of 10 rats were administered vanadium oxydichloride (labeled with vanadium-48) by intratracheal injection. Six replicates of the administration mode were performed. The average deposition in the respiratory tract was 1.0 +/- 0.1 µg (5.3 +/- 0.4 µCi) vanadium for the intratracheal injections. The activity median aerodynamic diameter, AMA, for the aerosol exposures averaged 0.76 microns with a geometric standard deviation of 1.96.
No further information on the exposure was stated. - Duration and frequency of treatment / exposure:
- Six replicates of the administration mode were performed.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
The average deposition in the respiratory tract was 1.0 +/- 0.1 µg (5.3 +/- 0.4 µCi) vanadium for the intratracheal injections. The activity median aerodynamic diameter, AMA, for the aerosol exposures averaged 0.76 microns with a geometric standard deviation of 1.96.
- No. of animals per sex per dose / concentration:
- 5 juvenile male rats and 5 mature male rats
- Control animals:
- not specified
- Positive control reference chemical:
- No data
- Details on study design:
- No data
- Details on dosing and sampling:
- Immediately following vanadium administration, the animals were placed in individual metabolism cages enabling collection of the urine and feces.
The animals were sacrificed at various times, 1/2, 2, 6, 24, or 96 hours post administration, and selected organs and tissues were removed and analyzed for their vanadium-48 content. The amount of vanadium-48 was determined using a large well NaI(TI) crystal detection system.
The urine and fecal values were used as indicators of systemic (absorbed) and unabsorbed vanadium, respectively.
No further information on the dosing and sampling was stated. - Statistics:
- No data
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- The absorption from the lungs following intratracheal injection was rapid with approximately 51 % of the administered dose remaining in the lungs at 30 minutes and 8.6 % remaining at 4 days.
- Results:
- The urine and fecal values were used as indicators of systemic (absorbed) and unabsorbed vanadium, respectively. From this study, an absorption value of 80 % from the lungs has been calculated.
- Results:
- In intratracheal injection mode of administration, the mature animals retained a larger percentage (8.5%) of the administered dose in the lungs than the juvenile animals (3.7%).
- Results:
- The juvenile animals initially had higher levels in the spleen than the mature animals but this difference disappeared at 4 days. The juvenile animals consistently had femur vanadium levels that were 50 to 100% above those in the mature animals.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The absorption from the lungs following intratracheal injection was rapid with approximately 51 % of the administered dose remaining in the lungs at 30 minutes and 8.6 % remaining at 4 days. The 0.76 micron AMAD aerosol generated for the inhalation administration favored deposition in the lungs and nasopharyngeal regions of the respiratory tract.
The urine and fecal values were used as indicators of systemic (absorbed) and unabsorbed vanadium, respectively. From this study, an absorption value of 80 % from the lungs has been calculated.
In intratracheal injection mode of administration, the mature animals retained a larger percentage (8.5%) of the administered dose in the lungs than the juvenile animals (3.7%). The juvenile animals initially had higher levels in the spleen but this difference disappeared at 4 days. The juvenile animals consistently had femur vanadium levels that were 50 to 100% above those in the mature animals. All other Tissues and excreta did not show differences attributable to the age of the experimental animals. - Details on distribution in tissues:
- No data
- Details on excretion:
- No data
Metabolite characterisation studies
- Metabolites identified:
- not specified
- Details on metabolites:
- No data
Applicant's summary and conclusion
- Conclusions:
- The absorption from the lungs following intratracheal injection was rapid with approximately 51 % of the administered dose remaining in the lungs at 30 minutes and 8.6 % remaining at 4 days. The 0.76 micron AMAD aerosol generated for the inhalation administration favored deposition in the lungs and nasopharyngeal regions of the respiratory tract.
The urine and fecal values were used as indicators of systemic (absorbed) and unabsorbed vanadium, respectively. From this study, an absorption value of 80 % from the lungs has been calculated.
In intratracheal injection mode of administration, the mature animals retained a larger percentage (8.5%) of the administered dose in the lungs than the juvenile animals (3.7%). The juvenile animals initially had higher levels in the spleen but this difference disappeared at 4 days. The juvenile animals consistently had femur vanadium levels that were 50 to 100% above those in the mature animals. All other tissues and excreta did not show differences attributable to the age of the experimental animals.
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