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EC number: 246-107-8 | CAS number: 24245-27-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
It was confirmed that the test item in doses of 5 mg/kg influences the activity of the cerebral cortex (outer layer of the brain). Thus, the test item has a stimulating effect - the response in the animals accelerates, then at one moment breaks down and there is no response any more. With doses at up to 1 mg/kg, no toxic effects on the nervous system were observed.
The dosage of 5 mg/kg turned out to be the lowest dose at which effects were observed. However, based on the conditions of this study these effects cannot be judged as adverse.
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Link to relevant study records
- Endpoint:
- neurotoxicity: chronic oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Using a method of conditioned reflexes in a chronic experiment the nature and extend of the effects of the test substance on the central nervous system of the tested animals was determined.
- GLP compliance:
- no
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- White male rats were tested.
Weight: 120 - 140 g
The rats were devided in 6 groups - 3 groups were treated with the source substance and 3 groups were treated with the target substance. Additionally, 2 groups were included as control groups. - Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on exposure:
- The test substances were were administered in equal volumes of destilled water at a rate of 1 mL per 100 g weight. The control group received the same amount distilled water as the treatment groups.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- Treatment: 4 months
- Frequency of treatment:
- 6 times a week
- Dose / conc.:
- 0.025 mg/kg bw/day (nominal)
- Dose / conc.:
- 0.5 mg/kg bw/day (nominal)
- Dose / conc.:
- 5 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- 5 males per treatment group
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- The source substance was tested in 3 treatments - 0.05, 1 and 10 mg/kg.
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 0.5 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- 5 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
- Key result
- Critical effects observed:
- no
- Conclusions:
- It was confirmed that the target test substance in doses of 5 mg/kg bw influences the activity of the cerebral cortex (outer layer of the brain). Thus, the test item has a stimulation effect - the response in the animals accelerates, then at one moment breaks down and there is no response any more. If the dose in up to 1 mg/kg bw, no toxic effects on the nervous system will be observed.
The dosage of 5 mg/kg bw turned out to be the lowest dose at which effects were observed. - Executive summary:
A study on white male rats was performed to determined the effects of the target test substance on the central nervous system. Six groups of 5 male rats each were treated. 3 concentrations of the target test substance - 0.025, 0.5 and 5 mg/kg bw, and 3 concentrations of the source substance - 0.05, 1 and 10 mg/kg bw were tested. Parallel ran 2 control groups. The tested substances were applied orally 6 times a week for 4 months. Using a method of conditioned reflexes in a chronic experiment the nature and extend of the effects of the test substance on the central nervous system of the tested animals was determined. The reflexes of the treated animals towards a bell sound were observed. The latent period and reflex signals were noted. Treated animals with 0.05 and 1 mg/kg bw source substance and with 0.025 and 0.5 mg/kg bw target substance showed no significant differences to the control groups. At the highest tested concentrations for both substances - 5 mg/kg bw for the target and 10 mg/kg bw for the source, inhibitory effects on the activity of the cerebral cortex were observed. The NOAEL for the target substance was determined to be 0.5 mg/kg bw, while the LOAEL was 5 mg/kg bw.
Reference
In the control groups the mean signal number was 43 with latent period of 0.92 +/- 0.06 seconds.
In treatments 0.05 and 1 mg/kg bw of the source substanmce, no signifficant differences with the control group were observed. In treatment group 10 mg/kg bw an effect was observed - the latent period was 1.9 +- 0.19 seconds, which was double the period of the control aminals. It is considered that at a dose level of 10 mg/kg bw the substance has an inhibitory effect of the central nervous system of white rates.
In treatments groups 0.025 and 0.5 mg/kg bw with the substance, no signifficant difference was observed with the control animals. Mean number of signals was 42 - 43. The latent period also did not differ with the one for the control animals. In the treatment of 5 mg/kg bw target substance an effect was observed. The latent period was decreased - 0.74 +- 0.06 seconds, compared to the control. The reaction period increased at 3.6 ,compared to 1.0 for the control animals. There was also some acceleration of the development of the reflex, but the reaction was strengthened even later than in the animals in the control group.
Differences in the strength of the motor reaction in experimental and control animals were not detected.
The reversability was fast and the normal reflexes in the animals were restored.
It was confirmed that the target test substance in doses of 5 mg/kg bw influences the activity of the cerebral cortex (outer layer of the brain). Thus, the test item has a stimulation effect - the responce in the animals accelerates, then at one moment breaks down and there is no responce more. If the dose in up to 1 mg/kg bw, no toxic effects on the nervous system will be observed.
The dosage of 5 mg/kg bw turned out to be the lowest dose at which effects were observed.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- 0.5 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A study on white male rats was performed to determined the effects of the target test substance on the central nervous system. Six groups of 5 male rats each were treated. 3 concentrations of the target test substance - 0.025, 0.5 and 5 mg/kg, and 3 concentrations of the source substance - 0.05, 1 and 10 mg/kg were tested. Parallel ran 2 control groups. The tested substances were applied orally 6 times a week for 4 months. Usind a method of conditioned reflexes in a chronic experiment the nature and extend of the effects of the test substance on the central nervous system of the tested animals was determined. The reflexes of the treated animals towards a bell sound were observed. The latent period and reflex signals were noted. Treated animals with 0.05 and 1 mg/kg source substance and with 0.025 and 0.5 mg/kg target substance showed no significant differences to the control groups. At the highest tested concentrations for both substances - 5 mgkg for the target and 10 mg/kg for the source, inhibitory effects on the activity of the cerebral cortex were observed. The NOEL for the test item was determined to be 0.5 mg/kg, while the LOEL was 5 mg/kg.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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