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EC number: 204-854-7 | CAS number: 127-65-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 January 1985 - 14 February 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was performed according to standard guideline and under GLP. Other test subtance was used.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Environmental Protection Agency (EPA Publication 54019-82-025)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Tosylchloramide sodium
- EC Number:
- 204-854-7
- EC Name:
- Tosylchloramide sodium
- Cas Number:
- 127-65-1
- Molecular formula:
- (C7H4SO2NCl)Na
- IUPAC Name:
- sodium chloro(4-methylbenzenesulfonyl)azanide
- Details on test material:
-
Ketjensept TC 500 gram (purity not described). The effect
concentration is reported as active ingredient.
Label: KETJENSEPT TC 500 gram (Chloramine-T trihydrate, CAS 7080-50-4)
Received From: R.W. Greeff & Co., Inc. 901 Dove Street, Suite 228 Newport Beach, California 92660
Date Received: December 19, 1984
Quantity Received: 1 kilogram
Physical Description: Fine white powder
Storage: Room temperature
Density: Not applicable
Purity and Composition: Not provided by sponsor
Stability: Not provided by sponsor
Concentration Administered: 8.00% w/v concentration in deionized water
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hsd: (Sd) BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague Dawley Inc, Houston Texas, USA
- Age at study initiation: young adult
- Weight at study initiation: males : 288 – 310 gram; female: 216 – 259 gram
- Fasting period before study: at least sixteen hours prior to treatment
- Housing: Cage Type: suspended wire bottom stainless steel. Housing: 1 - 3 per cage. Transfer to Clean Cages: Weekly. Litter Pan Lining: Paper and aspen bedding. Litter Pan Lining Change: Three times weekly.
- Diet (e.g. ad libitum): ad libitum, Purina Formulab Chow #5008
- Water (e.g. ad libitum): ad libitum, automatic
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: 31 January 1985 - 14 February 1985
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 8.00% w/v
- Amount of vehicle (if gavage): no data
- Justification for choice of vehicle: no data
MAXIMUM DOSE VOLUME APPLIED: no data - Doses:
- 8% w/v, this corresponds to and LD50 > 381.6 mg/kg for Chloramine-T.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations for mortality and pharmacologic and/or toxicologic effects were made at least three times on the day of treatment and at least once daily thereafter for fourteen days (day of treatment considered Day 0). Individual body weights were recorded just prior to treatment and on Days 8 and 14.
- Necropsy of survivors performed: yes; A gross necropsy examination was conducted on each animal at termination of the study.
- Other examinations performed: none - Statistics:
- no data
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 381.6 mg/kg bw
- Remarks on result:
- other: The acute oral LD-50 for actual KETJENSEPT TC as indicated by the data is greater than 5010 mg/kg (4.77 ml/kg) when administered as a 8.00% w/v concentration in deionized water to albino rats. This corresponds to and LD50 > 381.6 mg/kg for Chloramine-T.
- Mortality:
- No mortality.
- Clinical signs:
- other: Prominent in-life observations included activity decrease, constricted pupils, piloerection, dilated pupils, and sensitivity to touch.
- Gross pathology:
- No effects observed
Applicant's summary and conclusion
- Interpretation of results:
- other: Acute Tox. category 4
- Remarks:
- according to the classification criteria outlined in Annex I of 1272/2008/EC (CLP)
- Conclusions:
- The acute oral LD50 for actual KETJENSEPT TC as indicated by the data is greater than 5010 mg/kg (4.77 ml/kg) when administered as a 8.00% w/v concentration in deionized water to albino rats. This corresponds to and LD50 > 381.6 mg/kg for Tosylchloramide sodium.
- Executive summary:
An acute oral toxicity study was conducted on male and female albino rats using test material KETJENSEPT TC 500 gram (hereafter referred to as KETJENSEPT TC). This study was designed and performed in STILLMEADOW, Inc.'s AAALAC accredited laboratory under Pesticide Assessment Guidelines promulgated by the U.S. Environmental Protection Agency (EPA Publication 54019-82-025) and was in compliance with Good Laboratory Practice Standards (Fed. Reg. 48, 53946, 1983). The test material was administered as an 8.00% w/v concentration in deionized water. Five males and five females were dosed at a level of 5010 mg/kg (4.77 ml/kg). No animals died during the study. The acute oral LD-50 for actual KETJENSEPT TC as indicated by the data is greater than 5010 mg/kg (4.77 ml/kg) when administered as a 8.00% w/v concentration in deionized water to albino rats. This corresponds to and LD50 > 381.6 mg/kg for Tosylchloramide sodium.
The substance is classified as Acute oral toxic Cat 4 (H302) according to the classification criteria outlined in Annex I of 1272/2008/EC (CLP).
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