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Diss Factsheets
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EC number: 219-698-5 | CAS number: 2499-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Streigel JA and Nycum JS,
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal 30, 470-476
Materials and methods
- Principles of method if other than guideline:
- Primary skin irritation on rabbits is recorded in a 10-grade ordinal series and is based upon the severest reaction that develops on the clipped skin of each of five New Zealand albino rabbits within 24 hours of the uncovered application of 0.01 mL of undiluted sample.
- GLP compliance:
- no
- Remarks:
- Study predates GLP
Test material
- Reference substance name:
- Hexyl acrylate
- EC Number:
- 219-698-5
- EC Name:
- Hexyl acrylate
- Cas Number:
- 2499-95-8
- Molecular formula:
- C9H16O2
- IUPAC Name:
- hexyl prop-2-enoate
Constituent 1
- Specific details on test material used for the study:
- Specific details not provided
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Details on test animals and environmental conditions not provided
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- not specified
- Remarks:
- General method indicates vehicle could be water, propylene glycol or acetone
- Controls:
- not required
- Amount / concentration applied:
- 0.01 mL of undiluted sample or solutions in water, propylene glycol, or acetone.
- Duration of treatment / exposure:
- Duration of treatment/exposure: 24 h
- Observation period:
- Observation period: 24 h
- Number of animals:
- 5 Albino Rabbits
- Details on study design:
- Chemical was applied in 0.01 ml, amounts to clipped, uncovered intact skin of 5 rabbits either undiluted or in progressive dilutions of 10, 1, 0.1, and 0.01% in solvent. Ten grades are recognized based on appearance of moderate or marked capillary, erythema, edema or necrosis within 24 hours.
Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Irritation Grade based on scale in Carpenter et al. (1946)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 5
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Irritation grade 6.0 indicates necrosis when undiluted, therefore a score of grade 5.0 is indicative of irritation if not minimal necrosis.
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 2 (irritant) based on physiologic description
- Conclusions:
- Based on the irritation score of Grade 5.0, which corresponds to Necrosis, n-hexyl acrylate is considered irritating to the skin.
- Executive summary:
N-hexyl acrylate produced a skin irritation or corrosion score of Grade 5.0 (irritation/minimal necrosis) following 24 hour open application of 0.1 mL to 5 New Zeland White rabbits. While direct comparison of the grading shceme used in this study to current GHS criteria is not possible, this finding, evaluated within a weight of evidence approach, supports classification of N-hexyl Acrylate as a Category 2 Skin Irritant under the Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
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