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EC number: 219-698-5 | CAS number: 2499-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Toxicity- Oral LD50 = 22930 mg/kg in rats
Acute Toxicity- Dermal LD50 = 4983 mg/kg in rabbits
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Non-fasted animals were treated with a single dose by gastric intubation and observed during 14 days. This study was conducted as a range-finding test according to the method described by Smyth HF Jr. and Carpenter CP (1948).
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Source: Mellon Institute
-Age at study initiation: 4-5 weeks
-Weight at study initiation: 90-120 g
-Diet: Rockland Rodent diet
Water: ad-libitum - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Details on oral exposure: undiluted substance
- Doses:
- Logarithmic differing by a factor of 2 (no further detail)
- No. of animals per sex per dose:
- 5 Males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed daily for mortality; frequency of weighing not specified.
- Necropsy of survivors performed: no
- Statistics:
- LD 50 calculated by method of Thompson (Bacteri Rev 11: 115 June 1947 Use of moving averages and interpolation to estimate median effective dose) and tables of Weil (Biometrics 8: 249 Sept 1952: Tables for convenient calculation median-effective dose (LD50 or ED50) and instructions in their use). The LD50 is given with ± 1.96 standard deviations.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 22 932 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 18.9 - <= 35.8
- Remarks on result:
- other: original data: 26.0 ml/kg LD50 (mg/kg)= LD50 (ml/kg) x density x 1000 = 26.0 x 0.882 x 1000 = 22932.0 mg/kg
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 for n-hexyl acrylate following oral intubation was established at ca. 22392 mg/kg bw (26.0 mL/kg) for males. This finding does not warrant classification of n-hexyl acrylate as an acute oral toxicant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
- Executive summary:
In the key study (Smyth 1969), male rats were treated orally with single doses of n-hexyl acrylate and observed during 14 days. This study was conducted as a range-finding test according to the method described by Smyth HF Jr. and Carpenter CP (1948). The LD50 for n-hexyl acrylate following oral intubation was established at ca. 22392 mg/kg bw (26.0 mL/kg) for males. This finding does not warrant classification of n-hexyl acrylate as an acute oral toxicant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 22 930 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Male albino rabbits (3-5 months old) were immobilized during the 24-hour contact period with the compound retained under impervious sheeting on the clipped intact skin of the trunk. Thereafter, excess fluid is removed to prevent ingestion and animals are observed for 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: 3-5 months
- Weight at study initiation: 2.5 - 3.5 kg
- Fasting period before study: not specified
- Housing: not specified
- Diet (e.g. ad libitum): Rockland Rabbit Ration
- Water (e.g. ad libitum): not specified
- Acclimation period: not specified
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Details on dermal exposure: Male albino rabbits, 3 to 5 months of age are immobilized during the 24-hour contact period with the compound retained under impervious sheeting on the clipped intact skin of the trunk. Thereafter, the polyethylene sheeting used to retain the dose in contact with the clipped skin of the trunk was removed and the animals were observed for 14 days. Maximum dosage that can be achieved is 20 ml/kg
- Duration of exposure:
- Duration of exposure: 24 hours
- Doses:
- Logarithmic differing by a factor of 2 (no further detail)
- No. of animals per sex per dose:
- No. of animals per sex per dose: 4
- Control animals:
- no
- Details on study design:
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed daily for mortality; frequency of weighing not specified.
- Necropsy of survivors performed: no - Statistics:
- LD 50 calculated by method of Thompson (Bacteri Rev 11: 115 June 1947 Use of moving averages and interpolation to estimate median effective dose) and tables of Weil (Biometrics 8: 249 Sept 1952: Tables for convenient calculation median-effective dose (LD50 or ED50) and instructions in their use). The LD50 is given with ± 1.96 standard deviations.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 983 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 3.5 - < 9.14
- Remarks on result:
- other: original data: 5.65 ml/kg LD50 (mg/kg)= LD50 (ml/kg) x density x 1000 = 5.65 x 0.882 x 1000 = 4983 mg/kg
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- N-hexyl acrylate was administered via oral intubation to 4 male New Zealand White Rabbits to assess the acute oral toxicity. Animals were observed daily for 14 days post dosing. The LD50 for N-hexyl acrylate based on these data were established at 4893 mg/kg (5.65 ml/kg) for males. This finding does not warrant classification of N-hexyl acrylate as an acute oral toxicant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
- Executive summary:
N-hexyl acrylate is minimally toxic via ingestion where the LD50 was established at >2000 mg/kg in a range finding study. This finding does not warrant classification n-hexyl acrylate as an acute oral toxicant under the Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 983 mg/kg bw
Additional information
Justification for classification or non-classification
The LD50 for n-hexyl acrylate was established at 22930 mg/kg following oral intubation and 4983 mg/kg following dermal application. These findings do not warrant the classification of n-hexyl acrylate as an Acute toxicant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
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