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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Version / remarks:
1984
Deviations:
not specified
GLP compliance:
yes
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
72 h
Nominal and measured concentrations:
Test concentrations consisted of a control series and an additive control series (HCO-40, 100 mg/L). A limit test was conducted at the highest dispersion concentration of 100.0 mg/L. Concentrations were measure using HPLC upon start and completion of exposure.
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Key result
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Validity criteria fulfilled:
yes
Conclusions:
The test substance did not cause a reduction of growth in a series of algal cultures (test units) exposed to the test item for 72 h. The 72-h NOEC and the 72-h EC50 were each reported as ≥ 100 mg/L as determined by comparison of areas in growth curves. The 24-h to 48-h NOEC and the 72-h EC50 were each reported as ≥ 100 mg/L as determined by comparison of growth rates.

Description of key information

The test substance (TOTM, an analogue substance through read-across) did not cause a reduction of growth in a series of algal cultures (test units) exposed to the test item for 72 h.  The 72-h NOEC and the 72-h EC50 were each reprted as ≥ 100 mg/L as determined by comparison of areas in growth curves.  The 24-h to 48-h NOEC and the 72-h EC50 were each reported as ≥100 mg/L as determined by comparison of growth rates.

Key value for chemical safety assessment

EC50 for freshwater algae:
100 mg/L
EC10 or NOEC for freshwater algae:
100 mg/L

Additional information