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EC number: 262-980-8 | CAS number: 61788-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2nd February 1973 - 27 February 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- pre-dates 2002
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- pre-dates GLP
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Hexadecyl acetate
- EC Number:
- 211-103-7
- EC Name:
- Hexadecyl acetate
- Cas Number:
- 629-70-9
- Molecular formula:
- C18H36O2
- IUPAC Name:
- hexadecyl acetate
- Reference substance name:
- Acetic acid, esters with lanolin alcs.
- EC Number:
- 262-980-8
- EC Name:
- Acetic acid, esters with lanolin alcs.
- Cas Number:
- 61788-49-6
- Molecular formula:
- C29H48O2
- IUPAC Name:
- Acetic acid, esters with lanolin alcs.
- Test material form:
- liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 24 hours
- Acclimation period: 1 week
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2.5, 5.0, 10.0, 20 and 40 mL/kg
Equivalent to 200-450, 400-900, 800-1800, 1600-3600 and 3200-7200 mg/kg of the registered substance. - No. of animals per sex per dose:
- 1 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days)
- Frequency of observations: Daily
- Necropsy of survivors performed: no
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- act. ingr.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 40 mL/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed during the study
Any other information on results incl. tables
Table 1: Mortality (14 day observation period)
Dose (mL/kg) |
No. of rats dosed |
Mortality Day 1 |
Mortality Day 2 |
Mortality Day 3 |
Mortality Day 4 |
Mortality Day 5 |
Mortality Day 6 |
Mortality Day 7 |
Mortality Day 8 |
Mortality Day 9 |
Mortality Day 10 |
Mortality Day 11 |
Mortality Day 12 |
Mortality Day 13 |
Mortality Day 14 |
Mortality after 14 days |
2.5 mL/kg |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
5.0 mL/kg |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
10 mL/kg |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
20 mL/kg |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
40 mL/kg |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/2 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the test material in albino rats was determined to be greater than 40 mL/kg of the test material. This is equivalent to an LD50 of the registered material of greater than 3200 mg/kg.
- Executive summary:
The acute oral toxicity of the test material was evaluated in a study conducted in albino rats. The test material was administered to one male and one female in each of the dosing groups via stomach tube at the following doses 2.5, 5.0, 10.0, 20 and 40 mL/kg. This was equivalent to 200-450, 400-900, 800-1800, 1600-3600 and 3200-7200 mg/kg of the registered substance. The animals were observed for 14 days for signs of acute toxicity. No mortality was observed during the study. The LD50 of the test material in albino rats was determined to be greater than 40 mL/kg of the test material. This is equivalent to an LD50 of the registered material of greater than 3200 mg/kg.
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