Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
January 2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Remarks:
preliminary study used the flask method
Key result
Water solubility:
1.58 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
>= 6.92 - <= 7.52
Details on results:
During the preliminary test the water solubility of the test substance at room temperature was estimated by a simplified flask method to be lower than the smallest calibration point of 1.176 µg/mL. Therefore, the column elution method was used for the performance of the main test.
During the main test six samples have been analyzed in the first run (0.52 mL/min) and six samples during the second run (0.26 mL/min), each with a sampling interval of one hour. Total elution time was 93.5 hours. The sample measurements were performed by GC.
The measured results differ by less than 30% therefore, the study is considered to be valid.

The r2 fit of the calibration curve was 1.0000 (optimum). This reflects the linearity of the GC system within calibration range of 0.17675 mg/L to 17.675 mg/L of the test item.

In conclusion the water solubility of the test substance at 20°C was determined to be 1.58 mg/L (±0.35 mg/L) using the column elution method. (the water solubility was not corrected for the purity of the test item)

Results water solubility

Experiment No.

Flow rate [mL/h]

Sample No.

Concentration analyzed µg/mL

water solubility calculated [mg/L]

pH

1

31

1

1.30

1.58 SD = ± 0.35

6.92

2

1.67

6.95

3

1.34

7.08

4

1.94

7.13

5

2.08

6.97

6

2.20

6.99

2

16

1

1.20

7.52

2

1.18

7.27

3

1.32

7.05

4

1.45

6.78

5

1.56

6.94

6

1.71

7.00
Conclusions:
Under the conditions of the test, the water solubility of the test substance at 20°C was determined to be 1.58 mg/L (±0.35 mg/L).
Executive summary:

The water solubility of the test substance was determined according to OECD 105 and under GLP with the column elution method. Under the conditions of the test, the water solubility of the test substance at 20°C was determined to be 1.58 mg/L (±0.35 mg/L).

Description of key information

The water solubility of the test substance was determined according to OECD 105 and under GLP with the column elution method. Under the conditions of the test, the water solubility of the test substance at 20°C was determined to be 1.58 mg/L (±0.35 mg/L).

Key value for chemical safety assessment

Water solubility:
1.58 mg/L
at the temperature of:
20 °C

Additional information