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EC number: 244-971-0 | CAS number: 22413-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- Summary of available data used for the endpoint assessment of the target substance
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the analogue justification attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Parameter:
- % degradation (O2 consumption)
- Value:
- 75.3
- Sampling time:
- 28 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 86
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- no
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The target substance is readily biodegradable according to OECD criteria, based on experimental findings from a structurally closely related source substance (biodegradation is > 60% after 28 d, no 10-day window required, OECD 301C, CAS 17671-27-1).
Reference
Description of key information
Readily biodegradable: 75.3% (BOD) after 28 d (OECD 301C), read-across
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
No data are available on the biodegradation in water of the target substance docosyl stearate (CAS 22413-03-2). Thus, a weight of evidence approach is applied in accordance to the REACh Regulation (EC) No 1907/2006, Annex XI General rules for adaptation of the standard testing regime set out in Annexes VII to X, 1.2. The weight of evidence combines data on the read across substance docosyl docosanoate (CAS 17671-27-1) as well as (Q)SAR predictions (VEGA v1.2.3) for the target substance itself. The experimental data from the chemically and structurally closely related source substance docosyl docosanoate (CAS 17671-27-1) were used for read-across. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in within the analogue justification in IUCLID Section 13.
The study with the read-across substance docosyl docosanoate was performed according to OECD 301C (GLP) under aerobic conditions using a mixture of activated sludge from STP with freshwater from rivers and lakes, marine water and marine sediment as inoculum with a test substance concentration of 100 mg/L (Ministry of Economy, Trade and Industry, Japan, 1992). A biodegradation of 75.3% (BOD) was observed after 28 d. Since the substance reached the pass level for OECD 301C (biodegradation is > 60% after 28 d, no 10-day window required) docosyl docosanoate is readily biodegradable according to the OECD criteria.
Furthermore, the (Q)SAR model for ready biodegradability (VEGA v1.2.3, IRFMN 1.0.9) predicts ready biodegradability of the target substance itself. The substance lie within the applicability domain of the model and fulfilled all the measured applicability domain scores listed in the VEGA report (see endpoint study record). The overall model performance is good. Thus, the result is reliable and is considered adequate for regulatory purposes under Regulation (EC) No 1907/2006.
Based on the high degree of structural and chemical similarity between the target and the selected source substance, the target substance is expected to exhibit a similar environmental fate profile as the source substance. Therefore, it is concluded that the target substance docosyl stearate (CAS 22413-03-2) is readily biodegradable according to OECD guideline criteria, based on the available experimental results and QSAR prediction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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