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EC number: 239-044-2 | CAS number: 14970-87-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06/12/1992 to 08/06/1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Purity: 99,3 %
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- The inoculum was obtained the day of the ensemencement from the activated sludge of the biological wastewater treatment plant from Versailles (France, 78) which handles predominantly domestic sewage. On arrival at the laboratory, the activated sludge was centrifuged at 20°C (4000g for 20 minutes) and the solid sewage inoculum pellet was re-suspended in test medium in order to manage a ratio of 1:150 between the solid and the test medium. Total micro-organisms were counted with Total Count Millipore: for the present study, the concentration of the inoculum was 1,18.106 bact/mL thus a concentration of 1,18.104 bact/mL in the inoculated media (1% of inoculum in the test medium).
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 38.2 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- DOC removal
- Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- < 10
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- According to the OECD 301 guideline, the pass level for ready biodegradability is 70% removal of DOC for respirometric methods. This pass value has to be reached in a 10-d window within the 28-d period of the test. The 10-d window begins when the degree of biodegradation has reached 10% removal of DOC and must end before day 28 of the test.
In this study a mean total < 10% degradation was achieved by day 28. As a consequence the test item was not readily biodegradable under the conditions of the test. - Executive summary:
The study was conducted in accordance with procedures outlined in OECD Guideline 301A (1992). The ready biodegradability of the test item was assessed over a 28-day period.
The test was conducted at a nominal loading rate of 38.2 mg/L.
A total of 7 bioreactors were used:one for the procedure control, one for the sterile control, one for the inhibition control, one for the adsorption control and three for th test item.
The results of the test were as follows:
% biodegradation
(28 days)
Test item
Reference item
Toxicity Control
<10%
100%
57%
The test item was not readily biodegradable under the conditions of the test as it failed to achieve a transition from 10% to 70% degradation in a 10-day window during the 28-day test.
The test item was not considered to be inhibitory to the microbial inoculum since the biodegradation observed in the toxicity control bioreactor was not less than 35% occurred within 14 days.
The definitive test met the validity criteria of the test guideline detailed as follows:
- the difference of extremes of replicate values of the removal of the test item at the end of the test was less than 20%
- the percentage degradation of the reference compound has reached the pass level by day 14: > 70%
- the biodegradation observed in the toxicity control bioreactor was not less than 35%: 39% within 14 days,
Reference
Series | Flasks | Day 0 | Day 3 | Day 7 | Day 10 | Day 13 | Day 17 | Day 20 | Day 24 | Day 28 |
Test item | Ft1 | 0 | -15 | 0 | -18 | -13 | -17 | -4 | 4 | 7 |
Ft2 | 0 | -8 | 3 | -1 | -3 | -10 | 9 | -9 | 1 | |
Ft3 | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
Procedure control | Fc | 0 | 88 | 98 | 96 | 98 | 100 | 100 | 100 | 100 |
Sterile control | Fs | 0 | -6 | 5 | 2 | -7 | -1 | 8 | 8 | 3 |
Inhibition control | Fi | 0 | 46 | 54 | 46 | 39 | 47 | 58 | 50 | 57 |
Adsorption control | Fa | 0 | -3 | 10- | 7 | -1 | -7 | 16 | 6 | 9 |
Description of key information
The study was conducted in accordance with procedures outlined in OECD Guideline 301A (1992). The ready biodegradability of the test item was assessed over a 28-day period.
The test was conducted at a nominal loading rate of 38.2 mg/L.
A total of 7 bioreactors were used:one for the procedure control, one for the sterile control, one for the inhibition control, one for the adsorption control and three for th test item.
The results of the test were as follows:
% biodegradation (28 days) |
Test item |
Reference item |
Toxicity Control |
<10% |
100% |
57% |
The test item was not readily biodegradable under the conditions of the test as it failed to achieve a transition from 10% to 70% degradation in a 10-day window during the 28-day test.
The test item was not considered to be inhibitory to the microbial inoculum since the biodegradation observed in the toxicity control bioreactor was not less than 35% occurred within 14 days.
The definitive test met the validity criteria of the test guideline detailed as follows:
- the difference of extremes of replicate values of the removal of the test item at the end of the test was less than 20%
- the percentage degradation of the reference compound has reached the pass level by day 14: > 70%
- the biodegradation observed in the toxicity control bioreactor was not less than 35%: 39% within 14 days,
Key value for chemical safety assessment
Additional information
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