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EC number: 294-955-2 | CAS number: 91771-62-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cyperus scariosus, Cyperaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral Toxicity:
The acute oral toxicity dose (LD50) for Cyperus scariosus, ext. (CAS no.: 91771-62-9) was considered based on data available for the closely related read across chemicals. The LD50 value is >2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Cyperus scariosus, ext. cannot be classified for acute oral toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the closely related read across chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- WoE report is based on two acute oral toxicity studies as- WoE-2 and WoE-3Acute Oral toxicity test was carried out to study the effects of the test chemicals on rodents
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 1. not specified2. not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- 1. not specified2. not specified
- Doses:
- 1. 5000 mg/kg bw2. 5000 mg/kg bw
- No. of animals per sex per dose:
- 1. not specified2. not specified
- Control animals:
- not specified
- Details on study design:
- 1. not specified2. not specified
- Statistics:
- 1. not specified2. not specified
- Preliminary study:
- 1. not specified2. not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- 1. No mortality was observed at 5000 mg/kg bw.2. No mortality was observed at 5000 mg/kg bw.
- Clinical signs:
- other: 1. not specified2. not specified
- Gross pathology:
- 1. not specified2. not specified
- Other findings:
- 1. not specified2. not specified
- Interpretation of results:
- other: Not classified
- Conclusions:
- According to CLP regulation, the test chemical Cyperus scariosus, ext. (CAS no.: 91771-62-9) cannot be classified for acute oral toxicity, as the LD50 value is >2000 mg/kg bw.
- Executive summary:
Data available for the closely related read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Cyperus scariosus, ext. (CAS no.: 91771-62-9). The studies are as mentioned below:
1. The acute oral toxicity study was conducted by using test chemical in rats at the dose concentration of 5000 mg/kg bw via oral route. No mortality was observed at 5000 mg/kg bw. Therefore, LD50 value was considered to be >5000 mg/kg bw, when rats were treated with test chemical via oral route.
2. Acute oral toxicity study was conducted by using test chemical in rats at the dose concentration of 5000 mg/kg bw via oral route. No mortality was observed at 5000 mg/kg bw. Therefore, LD50 value was considered to be >5000 mg/kg bw, when rats were treated with test chemical via oral route.
Thus, based on the above summarised studies, Cyperus scariosus, ext. (CAS no.: 91771-62-9) and it’s closely related read across substances, it can be concluded that LD50 value is >2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Cyperus scariosus, ext. cannot be classified for acute oral toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from authoritative database.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral Toxicity:
Data available for the closely related read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Cyperus scariosus, ext. (CAS no.: 91771-62-9). The studies are as mentioned below:
1. The acute oral toxicity study was conducted by using test chemical in rats at the dose concentration of 5000 mg/kg bw via oral route. No mortality was observed at 5000 mg/kg bw. Therefore, LD50 value was considered to be >5000 mg/kg bw, when rats were treated with test chemical via oral route.
2. Acute oral toxicity study was conducted by using test chemical in rats at the dose concentration of 5000 mg/kg bw via oral route. No mortality was observed at 5000 mg/kg bw. Therefore, LD50 value was considered to be >5000 mg/kg bw, when rats were treated with test chemical via oral route.
Thus, based on the above summarised studies, Cyperus scariosus, ext. (CAS no.: 91771-62-9) and it’s closely related read across substances, it can be concluded that LD50 value is >2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Cyperus scariosus, ext. cannot be classified for acute oral toxicity.
Justification for classification or non-classification
Based on the above studies, Cyperus scariosus, ext. (CAS no.: 91771-62-9) and it’s closely related read across substances, it can be concluded that LD50 value is >2000 mg/kg bw for acute oral toxicity. Thus, comparing these values with the criteria of CLP regulation, Cyperus scariosus, ext. cannot be classified for acute oral toxicity.
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