Registration Dossier
Registration Dossier
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EC number: 207-894-3 | CAS number: 499-83-2
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas) Volume III.
- Author:
- Geiger,D.L., S.H. Poirier, L.T. Brooke, and D.J. Call,
- Year:
- 1 988
- Bibliographic source:
- information available on ECOTOX: Aquatic Report EPA
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no detailed information about the method reported but data from a reliable Database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Pyridine-2,6-dicarboxylic acid
- EC Number:
- 207-894-3
- EC Name:
- Pyridine-2,6-dicarboxylic acid
- Cas Number:
- 499-83-2
- Molecular formula:
- C7H5NO4
- IUPAC Name:
- pyridine-2,6-dicarboxylic acid
- Test material form:
- solid: crystalline
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- Age 33d
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 40.8 mg/L CaCO3
- Test temperature:
- 25.5 °C
- pH:
- 7.6
- Dissolved oxygen:
- 6.6 mg/L
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 d
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 322 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Affected fish lost schooling behavior, were hyperactive and overreactive to external stimuli, and had increased respiration
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 Fish (96 hours): 322 mg/l
- Executive summary:
LC50 Fish (96 hours): 322 mg/l
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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