Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 460-420-9 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.3
- GLP compliance:
- yes
- Limit test:
- yes
Test animals
- Species:
- other: rat, Sprague-Dawley HSD:SD
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: None
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
No deaths occurred. Two females showed loss of body weight
during the first week of the study. Two other animals showed
a slight loss of body weight at the end of the study.
Development of body weight was not impaired in male animals.
No symptoms were observed in male animals. Female animals
showed (starting on day 2) squatting posture, stilted and
uncoordinated gait, ataxia, drawn in flanks, irregular
respirations, hypoactivity, bristling coat, stupor,
mydriasis, straddled hind limbs and trembling.
From day 10 until the end of the study no symptoms were
observed. - Gross pathology:
- Effects on organs:
Animals killed at the end of the observation period showed
no macroscopically visible changes. - Other findings:
- Signs of toxicity (local):
The skin of all animals showed no signs of irritation.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
