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Diss Factsheets
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EC number: 240-968-3 | CAS number: 16919-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo insect germ cell study: gene mutation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- no guideline mentioned
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
- Specific details on test material used for the study:
- sodium hexafluorosilicate from Fisher Scientific Co., Fair Lawn, NJ (U.S.A.)
- Species / strain / cell type:
- S. typhimurium, other: TA1535, TA100, TA1538, TA98 and TA1537
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 liver fraction from Aroclor-pretreated rats
- Test concentrations with justification for top dose:
- Tests were performed according to standard procedures. In the Ames assay at least 5 doses, usually up to 3600 µg/plate for non-toxic and soluble compounds, were tested in all 5 strains with and without activation by the S9 liver fraction from Aroclor-pretreated rats.
- Vehicle / solvent:
- All compounds were tested on 2 slightly different minimal media: one (in the following named ZLM medium) is a modified minimal medium for E. coli, and the other is the Vogel-Bonner (VB) medium. ZLM medium contained (in g/l): tri-Na-citrate 2H2O (0.82), K2HP04 3H20 (4.60), KH2PO4 (1.50), (NH4)2SO4 (1.00), MgSO4 7H2O (0.10) and glucose (17.0). The concentration of citrate was 3.5 times higher in VB medium than in ZLM medium. The concentrations of the other ions are up to 2-fold higher in VB medium.
- Key result
- Species / strain:
- S. typhimurium, other:
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Conclusions:
- Sodium hexafluorosilicate showed negative results in the Ames test (with and without S9 activation).
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- genetic toxicity in vivo, other
- Remarks:
- micronucleus
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- no guideline mentioned
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- sodium hexafluorosilicate from Fisher Scientific Co., Fair Lawn, NJ (U.S.A.)
- Species:
- mouse
- Strain:
- NMRI
- Details on species / strain selection:
- Mice were obtained from S. Ivanovas GmbH and Co., Kisslegg/Allgäu (Germany)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were given standard chow (Altromin GmbH, Lage, Germany) and water ad libitum.
- Route of administration:
- intraperitoneal
- Frequency of treatment:
- once
- Dose / conc.:
- 37.6 mg/kg bw (total dose)
- No. of animals per sex per dose:
- 4 animals per dose (sex not specified)
- Control animals:
- yes, concurrent no treatment
- Additional information on results:
- Micronucleated polychromatic erythrocytes:
trearted: 0.2 %
control: 0.22 % - Conclusions:
- The effect was shown slightly more in control than in treated mice, therefore the substance was concluded to be not mutagenic.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- no guideline mentioned
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ammonium hexafluorosilicate
- EC Number:
- 240-968-3
- EC Name:
- Ammonium hexafluorosilicate
- Cas Number:
- 16919-19-0
- Molecular formula:
- F6Si.2H4N
- IUPAC Name:
- diammonium hexafluorosilicate
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- sodium hexafluorosilicate from Fisher Scientific Co., Fair Lawn, NJ (U.S.A.)
Test animals
- Species:
- Drosophila melanogaster
- Details on species / strain selection:
- The Berlin K (wild-type) and Base strains were used.
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- in 5% saccharose
- Details on exposure:
- In Drosophila one dose close to the LD50, was applied by the adult feeding method.
- Duration of treatment / exposure:
- 3 successive broods (3-3-4 days)
Doses / concentrations
- Dose / conc.:
- 0.25 other: mM
- Control animals:
- yes
- Positive control(s):
- trenimon
Results and discussion
- Additional information on results:
- Sex-linked recessive Iethals/chromosomes tested and percentage:
Brood 1: 3/1226 (0.24); control: 19/7130 (0.27)
Brood 2: 1/1224 (0.08); control: 8/5525 (0.14)
Brood 3: 2/1236 (0.16); control: 19/4871 (0.39)
Applicant's summary and conclusion
- Conclusions:
- Sodium hexaflurosilicate showed constantly slighter effects on drosophila than control over three generations.
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